Gene summary for NP_000018.1

Gene name
aspartylglucosaminidase
Symbol
AGA (Alias: AGA; AGU; ASRG; GA)
NCBI GeneID
175
Organism
Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000018.1 1..346
1
1..346
346

Structured regions (8)

PDB ID Chain Regions Mapppp help_icon
1APY A 2..162
1
2..162
346
1APY B 183..323
1
183..323
346
1APY C 2..162
1
2..162
346
1APY D 183..323
1
183..323
346
1APZ A 2..162
1
2..162
346
1APZ B 183..323
1
183..323
346
1APZ C 2..162
1
2..162
346
1APZ D 183..323
1
183..323
346

Domain / Motif regions (2)

Interpro ID Name Regions Map help_icon
IPR000246 (PTHR10188) Peptidase T2, asparaginase 2 72..323
1
72..323
346
IPR000246 (PF01112) Peptidase T2, asparaginase 2 11..333
1
11..333
346

Variant regions (0)

Non-synonymous SNPs (2)

dbSNP ID Residue change Regions Map help_icon
rs1138833 V → A 22..22
1
22..22
346
rs2228119 S → T 150..150
1
150..150
346

Interacting regions (1)

Interactants Ref. Relation # of rec. Region Map help_icon
TRIM27 Reference Domain/Motifs
  • 128 a.a. overlap with IPR000246 (PTHR10188).
  • 154 a.a. overlap with IPR000246 (PF01112).
SNPs
  • SNP:rs2228119 (Pos=150) falls into interacting region.
Structured region
  • 117 a.a. overlap with 1APY:A.
  • 17 a.a. overlap with 1APY:B.
  • 117 a.a. overlap with 1APY:C.
  • 17 a.a. overlap with 1APY:D.
  • 117 a.a. overlap with 1APZ:A.
  • 17 a.a. overlap with 1APZ:B.
  • 117 a.a. overlap with 1APZ:C.
  • 17 a.a. overlap with 1APZ:D.
Variant regions Interacting regions
1 46..199
1
46..199
346

Contacting amino acids (calculated from 3D structures) (24)

Interactants Structure Relation Chain Region Map help_icon
AGA 1APY:B Domain/Motifs
  • 39 a.a. overlap with IPR000246 (PTHR10188).
  • 96 a.a. overlap with IPR000246 (PF01112).
SNPs
  • SNP:rs1138833 (Pos=22) falls into interacting region.
Structured region
  • 105 a.a. overlap with 1APY:A.
  • 105 a.a. overlap with 1APY:C.
  • 105 a.a. overlap with 1APZ:A.
  • 105 a.a. overlap with 1APZ:C.
Variant regions
A 2..24, 27..42, 45..83, 86..90, 92..92, 102..106, 128..128, 130..136, 140..146, 159..159
1
2..24 27..42 45..83 86..90 92..92 102..106 128..128 130..136 140..146 159..159
346
AGA 1APY:C Domain/Motifs
  • 42 a.a. overlap with IPR000246 (PTHR10188).
  • 48 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 48 a.a. overlap with 1APY:A.
  • 48 a.a. overlap with 1APY:C.
  • 48 a.a. overlap with 1APZ:A.
  • 48 a.a. overlap with 1APZ:C.
Variant regions
A 57..59, 61..61, 63..63, 65..65, 73..73, 75..76, 80..83, 94..101, 103..112, 114..117, 143..149, 152..152, 158..162
1
57..59 61..61 63..63 65..65 73..73 75..76 80..83 94..101 103..112 114..117 143..149 152..152 158..162
346
AGA 1APY:D Domain/Motifs
  • 24 a.a. overlap with IPR000246 (PTHR10188).
  • 26 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 26 a.a. overlap with 1APY:A.
  • 26 a.a. overlap with 1APY:C.
  • 26 a.a. overlap with 1APZ:A.
  • 26 a.a. overlap with 1APZ:C.
Variant regions
A 69..69, 71..78, 80..80, 95..95, 98..112
1
69..69 71..78 80..80 95..95 98..112
346
AGA 1APY:A Domain/Motifs
  • 91 a.a. overlap with IPR000246 (PTHR10188).
  • 91 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 91 a.a. overlap with 1APY:B.
  • 91 a.a. overlap with 1APY:D.
  • 91 a.a. overlap with 1APZ:B.
  • 91 a.a. overlap with 1APZ:D.
Variant regions
B 183..227, 229..236, 238..238, 242..242, 247..247, 250..250, 254..254, 278..292, 300..300, 302..318
1
183..227 229..236 238..238 242..242 247..247 250..250 254..254 278..292 300..300 302..318
346
AGA 1APY:C Domain/Motifs
  • 24 a.a. overlap with IPR000246 (PTHR10188).
  • 24 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 24 a.a. overlap with 1APY:B.
  • 24 a.a. overlap with 1APY:D.
  • 24 a.a. overlap with 1APZ:B.
  • 24 a.a. overlap with 1APZ:D.
Variant regions
B 204..213, 216..217, 236..244, 269..269, 273..274
1
204..213 216..217 236..244 269..269 273..274
346
AGA 1APY:D Domain/Motifs
  • 28 a.a. overlap with IPR000246 (PTHR10188).
  • 28 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 28 a.a. overlap with 1APY:B.
  • 28 a.a. overlap with 1APY:D.
  • 28 a.a. overlap with 1APZ:B.
  • 28 a.a. overlap with 1APZ:D.
Variant regions
B 212..212, 216..220, 222..227, 241..245, 247..252, 254..255, 266..266, 269..269, 273..273
1
212..212 216..220 222..227 241..245 247..252 254..255 266..266 269..269 273..273
346
AGA 1APY:A Domain/Motifs
  • 41 a.a. overlap with IPR000246 (PTHR10188).
  • 47 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 47 a.a. overlap with 1APY:A.
  • 47 a.a. overlap with 1APY:C.
  • 47 a.a. overlap with 1APZ:A.
  • 47 a.a. overlap with 1APZ:C.
Variant regions
C 57..59, 61..61, 63..63, 65..65, 73..73, 75..76, 80..83, 94..101, 103..109, 111..112, 114..118, 143..148, 152..152, 158..162
1
57..59 61..61 63..63 65..65 73..73 75..76 80..83 94..101 103..109 111..112 114..118 143..148 152..152 158..162
346
AGA 1APY:B Domain/Motifs
  • 24 a.a. overlap with IPR000246 (PTHR10188).
  • 26 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 26 a.a. overlap with 1APY:A.
  • 26 a.a. overlap with 1APY:C.
  • 26 a.a. overlap with 1APZ:A.
  • 26 a.a. overlap with 1APZ:C.
Variant regions
C 69..69, 71..78, 95..96, 98..112
1
69..69 71..78 95..96 98..112
346
AGA 1APY:D Domain/Motifs
  • 41 a.a. overlap with IPR000246 (PTHR10188).
  • 97 a.a. overlap with IPR000246 (PF01112).
SNPs
  • SNP:rs1138833 (Pos=22) falls into interacting region.
Structured region
  • 106 a.a. overlap with 1APY:A.
  • 106 a.a. overlap with 1APY:C.
  • 106 a.a. overlap with 1APZ:A.
  • 106 a.a. overlap with 1APZ:C.
Variant regions
C 2..22, 24..24, 27..42, 45..83, 86..90, 92..92, 102..107, 128..128, 130..136, 138..138, 140..146, 159..159
1
2..22 24..24 27..42 45..83 86..90 92..92 102..107 128..128 130..136 138..138 140..146 159..159
346
AGA 1APY:A Domain/Motifs
  • 24 a.a. overlap with IPR000246 (PTHR10188).
  • 24 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 24 a.a. overlap with 1APY:B.
  • 24 a.a. overlap with 1APY:D.
  • 24 a.a. overlap with 1APZ:B.
  • 24 a.a. overlap with 1APZ:D.
Variant regions
D 204..213, 216..217, 236..244, 269..269, 273..274
1
204..213 216..217 236..244 269..269 273..274
346
AGA 1APY:B Domain/Motifs
  • 29 a.a. overlap with IPR000246 (PTHR10188).
  • 29 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 29 a.a. overlap with 1APY:B.
  • 29 a.a. overlap with 1APY:D.
  • 29 a.a. overlap with 1APZ:B.
  • 29 a.a. overlap with 1APZ:D.
Variant regions
D 212..212, 216..220, 222..228, 241..245, 247..252, 254..255, 266..266, 269..269, 273..273
1
212..212 216..220 222..228 241..245 247..252 254..255 266..266 269..269 273..273
346
AGA 1APY:C Domain/Motifs
  • 91 a.a. overlap with IPR000246 (PTHR10188).
  • 91 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 91 a.a. overlap with 1APY:B.
  • 91 a.a. overlap with 1APY:D.
  • 91 a.a. overlap with 1APZ:B.
  • 91 a.a. overlap with 1APZ:D.
Variant regions
D 183..227, 229..230, 232..236, 238..238, 242..242, 247..247, 250..250, 254..254, 278..292, 300..300, 302..319
1
183..227 229..230 232..236 238..238 242..242 247..247 250..250 254..254 278..292 300..300 302..319
346
AGA 1APZ:B Domain/Motifs
  • 37 a.a. overlap with IPR000246 (PTHR10188).
  • 94 a.a. overlap with IPR000246 (PF01112).
SNPs
  • SNP:rs1138833 (Pos=22) falls into interacting region.
Structured region
  • 103 a.a. overlap with 1APY:A.
  • 103 a.a. overlap with 1APY:C.
  • 103 a.a. overlap with 1APZ:A.
  • 103 a.a. overlap with 1APZ:C.
Variant regions
A 2..24, 27..42, 45..83, 86..90, 92..92, 102..103, 105..106, 128..128, 130..136, 140..146
1
2..24 27..42 45..83 86..90 92..92 102..103 105..106 128..128 130..136 140..146
346
AGA 1APZ:C Domain/Motifs
  • 41 a.a. overlap with IPR000246 (PTHR10188).
  • 47 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 47 a.a. overlap with 1APY:A.
  • 47 a.a. overlap with 1APY:C.
  • 47 a.a. overlap with 1APZ:A.
  • 47 a.a. overlap with 1APZ:C.
Variant regions
A 57..59, 61..61, 63..63, 70..70, 73..73, 75..76, 80..83, 94..101, 103..112, 114..117, 143..148, 152..152, 158..162
1
57..59 61..61 63..63 70..70 73..73 75..76 80..83 94..101 103..112 114..117 143..148 152..152 158..162
346
AGA 1APZ:D Domain/Motifs
  • 24 a.a. overlap with IPR000246 (PTHR10188).
  • 26 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 26 a.a. overlap with 1APY:A.
  • 26 a.a. overlap with 1APY:C.
  • 26 a.a. overlap with 1APZ:A.
  • 26 a.a. overlap with 1APZ:C.
Variant regions
A 69..69, 71..78, 80..80, 95..95, 98..112
1
69..69 71..78 80..80 95..95 98..112
346
AGA 1APZ:A Domain/Motifs
  • 91 a.a. overlap with IPR000246 (PTHR10188).
  • 91 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 91 a.a. overlap with 1APY:B.
  • 91 a.a. overlap with 1APY:D.
  • 91 a.a. overlap with 1APZ:B.
  • 91 a.a. overlap with 1APZ:D.
Variant regions
B 183..227, 229..229, 231..236, 238..238, 242..242, 246..247, 254..254, 278..292, 300..300, 302..319
1
183..227 229..229 231..236 238..238 242..242 246..247 254..254 278..292 300..300 302..319
346
AGA 1APZ:C Domain/Motifs
  • 25 a.a. overlap with IPR000246 (PTHR10188).
  • 25 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 25 a.a. overlap with 1APY:B.
  • 25 a.a. overlap with 1APY:D.
  • 25 a.a. overlap with 1APZ:B.
  • 25 a.a. overlap with 1APZ:D.
Variant regions
B 204..214, 216..217, 236..243, 269..270, 273..274
1
204..214 216..217 236..243 269..270 273..274
346
AGA 1APZ:D Domain/Motifs
  • 24 a.a. overlap with IPR000246 (PTHR10188).
  • 24 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 24 a.a. overlap with 1APY:B.
  • 24 a.a. overlap with 1APY:D.
  • 24 a.a. overlap with 1APZ:B.
  • 24 a.a. overlap with 1APZ:D.
Variant regions
B 216..220, 223..223, 225..225, 227..227, 241..245, 247..249, 251..252, 254..255, 266..266, 269..269, 272..273
1
216..220 223..223 225..225 227..227 241..245 247..249 251..252 254..255 266..266 269..269 272..273
346
AGA 1APZ:A Domain/Motifs
  • 41 a.a. overlap with IPR000246 (PTHR10188).
  • 46 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 46 a.a. overlap with 1APY:A.
  • 46 a.a. overlap with 1APY:C.
  • 46 a.a. overlap with 1APZ:A.
  • 46 a.a. overlap with 1APZ:C.
Variant regions
C 57..59, 61..61, 63..63, 73..73, 75..76, 80..83, 94..101, 103..109, 111..112, 114..117, 143..149, 152..152, 158..162
1
57..59 61..61 63..63 73..73 75..76 80..83 94..101 103..109 111..112 114..117 143..149 152..152 158..162
346
AGA 1APZ:B Domain/Motifs
  • 24 a.a. overlap with IPR000246 (PTHR10188).
  • 26 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 26 a.a. overlap with 1APY:A.
  • 26 a.a. overlap with 1APY:C.
  • 26 a.a. overlap with 1APZ:A.
  • 26 a.a. overlap with 1APZ:C.
Variant regions
C 69..69, 71..78, 95..96, 98..112
1
69..69 71..78 95..96 98..112
346
AGA 1APZ:D Domain/Motifs
  • 40 a.a. overlap with IPR000246 (PTHR10188).
  • 97 a.a. overlap with IPR000246 (PF01112).
SNPs
  • SNP:rs1138833 (Pos=22) falls into interacting region.
Structured region
  • 106 a.a. overlap with 1APY:A.
  • 106 a.a. overlap with 1APY:C.
  • 106 a.a. overlap with 1APZ:A.
  • 106 a.a. overlap with 1APZ:C.
Variant regions
C 2..24, 27..42, 45..83, 86..90, 92..92, 102..107, 128..128, 131..136, 138..138, 140..146, 159..159
1
2..24 27..42 45..83 86..90 92..92 102..107 128..128 131..136 138..138 140..146 159..159
346
AGA 1APZ:A Domain/Motifs
  • 25 a.a. overlap with IPR000246 (PTHR10188).
  • 25 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 25 a.a. overlap with 1APY:B.
  • 25 a.a. overlap with 1APY:D.
  • 25 a.a. overlap with 1APZ:B.
  • 25 a.a. overlap with 1APZ:D.
Variant regions
D 204..214, 216..217, 236..244, 269..269, 273..274
1
204..214 216..217 236..244 269..269 273..274
346
AGA 1APZ:B Domain/Motifs
  • 27 a.a. overlap with IPR000246 (PTHR10188).
  • 27 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 27 a.a. overlap with 1APY:B.
  • 27 a.a. overlap with 1APY:D.
  • 27 a.a. overlap with 1APZ:B.
  • 27 a.a. overlap with 1APZ:D.
Variant regions
D 212..213, 216..220, 223..223, 225..225, 227..228, 238..238, 241..245, 247..248, 250..252, 254..255, 266..266, 269..269, 273..273
1
212..213 216..220 223..223 225..225 227..228 238..238 241..245 247..248 250..252 254..255 266..266 269..269 273..273
346
AGA 1APZ:C Domain/Motifs
  • 90 a.a. overlap with IPR000246 (PTHR10188).
  • 90 a.a. overlap with IPR000246 (PF01112).
SNPs Structured region
  • 90 a.a. overlap with 1APY:B.
  • 90 a.a. overlap with 1APY:D.
  • 90 a.a. overlap with 1APZ:B.
  • 90 a.a. overlap with 1APZ:D.
Variant regions
D 183..227, 229..230, 232..236, 238..238, 241..242, 254..254, 278..292, 300..300, 302..319
1
183..227 229..230 232..236 238..238 241..242 254..254 278..292 300..300 302..319
346

Custom regions (0)

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