Gene summary for NP_000025.1

Gene name
aldolase A, fructose-bisphosphate
Symbol
ALDOA (Alias: ALDOA; ALDA; GSD12; MGC10942; MGC17716; MGC17767)
NCBI GeneID
226
Organism
Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000025.1 1..364
1
1..364
364

Structured regions (3)

PDB ID Chain Regions Mapppp help_icon
1ALD A 1..363
1
1..363
364
2ALD A 1..363
1
1..363
364
4ALD A 1..363
1
1..363
364

Domain / Motif regions (4)

Interpro ID Name Regions Map help_icon
IPR000741 (PTHR11627) Fructose-bisphosphate aldolase, class-I 1..364
1
1..364
364
IPR000741 (PF00274) Fructose-bisphosphate aldolase, class-I 15..364
1
15..364
364
IPR000741 (PS00158) Fructose-bisphosphate aldolase, class-I 222..232
1
222..232
364
IPR013785 (G3DSA:3.20.20.70) Aldolase-type TIM barrel 5..361
1
5..361
364

Variant regions (0)

Non-synonymous SNPs (13)

dbSNP ID Residue change Regions Map help_icon
rs11553106 A → V 34..34
1
34..34
364
rs11553107 E → Q 83..83
1
83..83
364
rs11553108 G → V 143..143
1
143..143
364
rs11553111 P → W 39..39
1
39..39
364
rs11553113 R → C 135..135
1
135..135
364
rs11553114 A → D 28..28
1
28..28
364
rs11553115 G → S 42..42
1
42..42
364
rs11553116 E → K 157..157
1
157..157
364
rs11553121 S → T 177..177
1
177..177
364
rs3098412 A → G 74..74
1
74..74
364
rs3098416 A → S 281..281
1
281..281
364
rs3112557 D → A 197..197
1
197..197
364
rs3134626 K → N 231..231
1
231..231
364

Interacting regions (2)

Interactants Ref. Relation # of rec. Region Map help_icon
HDAC4 Reference Domain/Motifs
  • 50 a.a. overlap with IPR000741 (PTHR11627).
  • 36 a.a. overlap with IPR000741 (PF00274).
  • 46 a.a. overlap with IPR013785 (G3DSA:3.20.20.70).
SNPs
  • SNP:rs11553106 (Pos=34) falls into interacting region.
  • SNP:rs11553111 (Pos=39) falls into interacting region.
  • SNP:rs11553114 (Pos=28) falls into interacting region.
  • SNP:rs11553115 (Pos=42) falls into interacting region.
Structured region
  • 50 a.a. overlap with 1ALD:A.
  • 50 a.a. overlap with 2ALD:A.
  • 50 a.a. overlap with 4ALD:A.
Variant regions Interacting regions
1 1..50
1
1..50
364
PPP5C Reference Domain/Motifs
  • 111 a.a. overlap with IPR000741 (PTHR11627).
  • 111 a.a. overlap with IPR000741 (PF00274).
  • 4 a.a. overlap with IPR000741 (PS00158).
  • 111 a.a. overlap with IPR013785 (G3DSA:3.20.20.70).
SNPs
  • SNP:rs11553108 (Pos=143) falls into interacting region.
  • SNP:rs11553113 (Pos=135) falls into interacting region.
  • SNP:rs11553116 (Pos=157) falls into interacting region.
  • SNP:rs11553121 (Pos=177) falls into interacting region.
  • SNP:rs3112557 (Pos=197) falls into interacting region.
Structured region
  • 111 a.a. overlap with 1ALD:A.
  • 111 a.a. overlap with 2ALD:A.
  • 111 a.a. overlap with 4ALD:A.
Variant regions Interacting regions
1 115..225
1
115..225
364

Contacting amino acids (calculated from 3D structures) (0)

Custom regions (0)

Add custom regions

help_icon

Add a custom region

..

Add multiple custom regions