Gene summary for NP_000029.2

Gene name
adenomatous polyposis coli
Symbol
APC (Alias: APC; BTPS2; DP2; DP2.5; DP3; GS)
NCBI GeneID
324
Organism
Homo sapiens
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Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000029.2 1..2843
1
1..2843
2843

Structured regions (7)

PDB ID Chain Regions Mapppp help_icon
1DEB A 2..55
1
2..55
2843
1EMU B 2035..2050
1
2035..2050
2843
1JPP C 1021..1031
1
1021..1031
2843
1M5I A 130..239
1
130..239
2843
1T08 C 1484..1498
1
1484..1498
2843
1TH1 C 1468..1529
1
1468..1529
2843
1V18 B 1485..1528
1
1485..1528
2843

Domain / Motif regions (10)

Interpro ID Name Regions Map help_icon
IPR000225 (PF00514) Armadillo 522..552, 649..689, 691..730
1
522..552 649..689 691..730
2843
IPR000225 (PS50176) Armadillo 660..702
1
660..702
2843
IPR000225 (SM00185) Armadillo 340..392, 459..510, 512..553, 556..597, 599..644, 649..689
1
340..392 459..510 512..553 556..597 599..644 649..689
2843
IPR009223 (PF05923) APC cysteine-rich 1256..1281, 1370..1394, 1486..1510, 1637..1661, 1841..1866, 1948..1973, 2008..2031
1
1256..1281 1370..1394 1486..1510 1637..1661 1841..1866 1948..1973 2008..2031
2843
IPR009224 (PF05924) SAMP 1569..1589, 1719..1738, 2034..2051
1
1569..1589 1719..1738 2034..2051
2843
IPR009232 (PF05937) EB-1 binding 2670..2843
1
2670..2843
2843
IPR009234 (PF05956) APC basic 2223..2579
1
2223..2579
2843
IPR009240 (PF05972) APC 15 residue 1020..1035, 1136..1151, 1155..1170, 1172..1186
1
1020..1035 1136..1151 1155..1170 1172..1186
2843
IPR011989 (G3DSA:1.25.10.10) Armadillo-like helical 288..730
1
288..730
2843
IPR016024 (SSF48371) Armadillo-type fold 121..729
1
121..729
2843

Variant regions (0)

Non-synonymous SNPs (2)

dbSNP ID Residue change Regions Map help_icon
rs377860 K → Q 1371..1371
1
1371..1371
2843
rs459552 V → D 1823..1823
1
1823..1823
2843

Interacting regions (2)

Interactants Ref. Relation # of rec. Region Map help_icon
CTNNB1 Reference Domain/Motifs
  • 51 a.a. overlap with IPR009223 (PF05923).
  • 41 a.a. overlap with IPR009224 (PF05924).
SNPs
  • SNP:rs459552 (Pos=1823) falls into interacting region.
Structured region Variant regions Interacting regions 		1 1546..1908
1
1546..1908
2843
CTNNB1 Reference Domain/Motifs
  • 26 a.a. overlap with IPR009223 (PF05923).
  • 15 a.a. overlap with IPR009224 (PF05924).
SNPs
  • SNP:rs459552 (Pos=1823) falls into interacting region.
Structured region Variant regions Interacting regions 		1 1724..1897
1
1724..1897
2843

Contacting amino acids (calculated from 3D structures) (3)

Interactants Structure Relation Chain Region Map help_icon
AXIN1 1EMU:A Domain/Motifs
  • 15 a.a. overlap with IPR009224 (PF05924).
SNPs Structured region
  • 15 a.a. overlap with 1EMU:B.
Variant regions 		B 2035..2037, 2039..2050
1
2035..2037 2039..2050
2843
CTNNB1 1T08:A Domain/Motifs
  • 12 a.a. overlap with IPR009223 (PF05923).
SNPs Structured region
  • 14 a.a. overlap with 1T08:C.
  • 14 a.a. overlap with 1TH1:C.
  • 13 a.a. overlap with 1V18:B.
Variant regions 		C 1484..1497
1
1484..1497
2843
CTNNB1 1TH1:A Domain/Motifs
  • 19 a.a. overlap with IPR009223 (PF05923).
SNPs Structured region
  • 13 a.a. overlap with 1T08:C.
  • 55 a.a. overlap with 1TH1:C.
  • 38 a.a. overlap with 1V18:B.
Variant regions 		C 1468..1478, 1480..1496, 1503..1529
1
1468..1478 1480..1496 1503..1529
2843

Custom regions (0)

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