Gene summary for NP_000029.2
- Gene name
- adenomatous polyposis coli
- Symbol
- APC (Alias: APC; BTPS2; DP2; DP2.5; DP3; GS)
- NCBI GeneID
- 324
- Organism
- Homo sapiens
Protein sequences and regions
Structured regions (7)
Domain / Motif regions (10)
Interpro ID | Name | Regions | Map | ![]() |
---|---|---|---|---|
IPR000225 (PF00514) | Armadillo | 522..552, 649..689, 691..730 |
1
522..552
649..689
691..730
2843
|
|
IPR000225 (PS50176) | Armadillo | 660..702 |
1
660..702
2843
|
|
IPR000225 (SM00185) | Armadillo | 340..392, 459..510, 512..553, 556..597, 599..644, 649..689 |
1
340..392
459..510
512..553
556..597
599..644
649..689
2843
|
|
IPR009223 (PF05923) | APC cysteine-rich | 1256..1281, 1370..1394, 1486..1510, 1637..1661, 1841..1866, 1948..1973, 2008..2031 |
1
1256..1281
1370..1394
1486..1510
1637..1661
1841..1866
1948..1973
2008..2031
2843
|
|
IPR009224 (PF05924) | SAMP | 1569..1589, 1719..1738, 2034..2051 |
1
1569..1589
1719..1738
2034..2051
2843
|
|
IPR009232 (PF05937) | EB-1 binding | 2670..2843 |
1
2670..2843
2843
|
|
IPR009234 (PF05956) | APC basic | 2223..2579 |
1
2223..2579
2843
|
|
IPR009240 (PF05972) | APC 15 residue | 1020..1035, 1136..1151, 1155..1170, 1172..1186 |
1
1020..1035
1136..1151
1155..1170
1172..1186
2843
|
|
IPR011989 (G3DSA:1.25.10.10) | Armadillo-like helical | 288..730 |
1
288..730
2843
|
|
IPR016024 (SSF48371) | Armadillo-type fold | 121..729 |
1
121..729
2843
|
Variant regions (0)
Non-synonymous SNPs (2)
Interacting regions (2)
Interactants | Ref. | Relation | # of rec. | Region | Map | ![]() |
---|---|---|---|---|---|---|
CTNNB1 |
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1 | 1546..1908 |
1
1546..1908
2843
|
|
CTNNB1 |
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1 | 1724..1897 |
1
1724..1897
2843
|
Contacting amino acids (calculated from 3D structures) (3)
Interactants | Structure | Relation | Chain | Region | Map | ![]() |
---|---|---|---|---|---|---|
AXIN1 | 1EMU:A |
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B | 2035..2037, 2039..2050 |
1
2035..2037
2039..2050
2843
|
|
CTNNB1 | 1T08:A |
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C | 1484..1497 |
1
1484..1497
2843
|
|
CTNNB1 | 1TH1:A |
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C | 1468..1478, 1480..1496, 1503..1529 |
1
1468..1478
1480..1496
1503..1529
2843
|