Gene summary for NP_000032.1

Gene name
apolipoprotein E
Symbol
APOE (Alias: APOE; AD2; LDLCQ5; LPG; MGC1571)
NCBI GeneID
348
Organism
Homo sapiens
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Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000032.1 1..317
1
1..317
317

Structured regions (12)

PDB ID Chain Regions Mapppp help_icon
1B68 A 41..101, 104..129, 131..180
1
41..101 104..129 131..180
317
1BZ4 A 22..165
1
22..165
317
1EA8 A 23..162
1
23..162
317
1GS9 A 22..165
1
22..165
317
1H7I A 23..162
1
23..162
317
1LE2 A 23..166
1
23..166
317
1LE4 A 42..129, 131..180
1
42..129 131..180
317
1LPE A 23..166
1
23..166
317
1NFN A 23..164
1
23..164
317
1NFO A 23..163
1
23..163
317
1OR2 A 23..163
1
23..163
317
1OR3 A 22..164
1
22..164
317

Domain / Motif regions (2)

Interpro ID Name Regions Map help_icon
IPR000074 (PF01442) Apolipoprotein A1/A4/E 81..299
1
81..299
317
IPR013326 (G3DSA:1.20.120.20) Apolipoprotein/apolipophorin 40..183
1
40..183
317

Variant regions (0)

Non-synonymous SNPs (18)

dbSNP ID Residue change Regions Map help_icon
rs11083750 P → Q 103..103
1
103..103
317
rs11542027 S → F 216..216
1
216..216
317
rs11542029 R → C 51..51
1
51..51
317
rs11542030 Q → R 206..206
1
206..206
317
rs11542032 S → K 190..190
1
190..190
317
rs11542034 E → G 151..151
1
151..151
317
rs11542035 R → H 138..138
1
138..138
317
rs11542040 P → T 103..103
1
103..103
317
rs11542041 R → S 133..133
1
133..133
317
rs28931576 T → A 61..61
1
61..61
317
rs28931577 A → T 118..118
1
118..118
317
rs28931578 R → Q 153..153
1
153..153
317
rs28931579 S → R 315..315
1
315..315
317
rs41382345 E → V 140..140
1
140..140
317
rs429358 H → R 131..131
1
131..131
317
rs7412 R → C 177..177
1
177..177
317
rs769452 L → P 47..47
1
47..47
317
rs769455 R → C 164..164
1
164..164
317

Interacting regions (3)

Interactants Ref. Relation # of rec. Region Map help_icon
PKNOX1 Reference Domain/Motifs
  • 11 a.a. overlap with IPR000074 (PF01442).
  • 52 a.a. overlap with IPR013326 (G3DSA:1.20.120.20).
SNPs
  • SNP:rs11542029 (Pos=51) falls into interacting region.
  • SNP:rs28931576 (Pos=61) falls into interacting region.
  • SNP:rs769452 (Pos=47) falls into interacting region.
Structured region
  • 51 a.a. overlap with 1B68:A.
  • 70 a.a. overlap with 1BZ4:A.
  • 69 a.a. overlap with 1EA8:A.
  • 70 a.a. overlap with 1GS9:A.
  • 69 a.a. overlap with 1H7I:A.
  • 69 a.a. overlap with 1LE2:A.
  • 50 a.a. overlap with 1LE4:A.
  • 69 a.a. overlap with 1LPE:A.
  • 69 a.a. overlap with 1NFN:A.
  • 69 a.a. overlap with 1NFO:A.
  • 69 a.a. overlap with 1OR2:A.
  • 70 a.a. overlap with 1OR3:A.
Variant regions Interacting regions
  • overlap with IKBKG interacting region.
 1 20..91
1
20..91
317
PKNOX1 Reference Domain/Motifs
  • 22 a.a. overlap with IPR000074 (PF01442).
  • 63 a.a. overlap with IPR013326 (G3DSA:1.20.120.20).
SNPs
  • SNP:rs11542029 (Pos=51) falls into interacting region.
  • SNP:rs28931576 (Pos=61) falls into interacting region.
  • SNP:rs769452 (Pos=47) falls into interacting region.
Structured region
  • 61 a.a. overlap with 1B68:A.
  • 76 a.a. overlap with 1BZ4:A.
  • 76 a.a. overlap with 1EA8:A.
  • 76 a.a. overlap with 1GS9:A.
  • 76 a.a. overlap with 1H7I:A.
  • 76 a.a. overlap with 1LE2:A.
  • 61 a.a. overlap with 1LE4:A.
  • 76 a.a. overlap with 1LPE:A.
  • 76 a.a. overlap with 1NFN:A.
  • 76 a.a. overlap with 1NFO:A.
  • 76 a.a. overlap with 1OR2:A.
  • 76 a.a. overlap with 1OR3:A.
Variant regions Interacting regions
  • overlap with IKBKG interacting region.
 1 27..102
1
27..102
317
IKBKG Reference Domain/Motifs
  • 17 a.a. overlap with IPR000074 (PF01442).
  • 29 a.a. overlap with IPR013326 (G3DSA:1.20.120.20).
SNPs Structured region
  • 29 a.a. overlap with 1B68:A.
  • 29 a.a. overlap with 1BZ4:A.
  • 29 a.a. overlap with 1EA8:A.
  • 29 a.a. overlap with 1GS9:A.
  • 29 a.a. overlap with 1H7I:A.
  • 29 a.a. overlap with 1LE2:A.
  • 29 a.a. overlap with 1LE4:A.
  • 29 a.a. overlap with 1LPE:A.
  • 29 a.a. overlap with 1NFN:A.
  • 29 a.a. overlap with 1NFO:A.
  • 29 a.a. overlap with 1OR2:A.
  • 29 a.a. overlap with 1OR3:A.
Variant regions Interacting regions
  • overlap with PKNOX1 interacting region.
 1 69..97
1
69..97
317

Contacting amino acids (calculated from 3D structures) (0)

Custom regions (0)

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