Gene summary for NP_000101.2
- Gene name
- dihydropyrimidine dehydrogenase
- Symbol
- DPYD (Alias: DPYD; DHP; DHPDHASE; DPD; MGC132008; MGC70799)
- NCBI GeneID
- 1806
- Organism
- Homo sapiens
Protein sequences and regions
Structured regions (0)
Structure mapping
Domain / Motif regions (10)
Interpro ID | Name | Regions | Map | ![]() |
---|---|---|---|---|
IPR000759 (PR00419) | Adrenodoxin reductase | 189..211, 213..226, 335..349 |
1
189..211
213..226
335..349
1025
|
|
IPR005720 (TIGR01037) | Dihydroorotate dehydrogenase, class 1, core | 533..854 |
1
533..854
1025
|
|
IPR009051 (SSF46548) | Alpha-helical ferredoxin | 2..198 |
1
2..198
1025
|
|
IPR012135 (PF01180) | Dihydroorotate dehydrogenase, class 1/ 2 | 534..838 |
1
534..838
1025
|
|
IPR012285 (G3DSA:1.10.1060.10) | Fumarate reductase, C-terminal | 27..183 |
1
27..183
1025
|
|
IPR013027 (PF07992) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | 190..484 |
1
190..484
1025
|
|
IPR013785 (G3DSA:3.20.20.70) | Aldolase-type TIM barrel | 533..844 |
1
533..844
1025
|
|
IPR016040 (G3DSA:3.40.50.720) | NAD(P)-binding domain | 184..532 |
1
184..532
1025
|
|
IPR017896 (PS51379) | 4Fe-4S ferredoxin, iron-sulpur binding domain | 69..100, 944..976, 978..1007 |
1
69..100
944..976
978..1007
1025
|
|
IPR017900 (PS00198) | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site | 986..997 |
1
986..997
1025
|
Variant regions (0)
Non-synonymous SNPs (6)
Interacting regions (1)
Interactants | Ref. | Relation | # of rec. | Region | Map | ![]() |
---|---|---|---|---|---|---|
SMAD7 |
![]() |
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1 | 65..66, 71..72, 76..76, 79..79, 82..83, 85..85, 87..87, 91..91, 93..93, 111..113, 123..123, 125..126, 130..130, 136..136, 138..138, 140..140 |
1
65..66
71..72
76..76
79..79
82..83
85..85
87..87
91..91
93..93
111..113
123..123
125..126
130..130
136..136
138..138
140..140
1025
|