Region information - IRView

Gene summary for NP_000101.2

Gene name: dihydropyrimidine dehydrogenase
Symbol: DPYD (Alias: DPYD; DHP; DHPDHASE; DPD; MGC132008; MGC70799)
NCBI GeneID: 1806
Organism: Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID	Region	Map
NP_000101.2	1..1025	1 1..1025 1025

Related sequences (14)

Protein ID	Length	Regions	Map
Q12882	1025	1..909, 911..1025	1 1..909 911..1025 1025
Q32NB0	173	1..130, 132..161	1 1..130 132..161 1025
Q5VXW9	1025	1..28, 30..1025	1 1..28 30..1025 1025
Q96HL6	173	1..161	1 1..161 1025
AAA57474.1	1025	1..909, 911..1025	1 1..909 911..1025 1025
AAB51366.1	1025	1..1025	1 1..1025 1025
AAH08379.1	173	1..161	1 1..161 1025
AAH64027.1	173	1..161	1 1..161 1025
AAI08743.1	173	1..130, 132..161	1 1..130 132..161 1025
AAI31778.1	1025	1..542, 544..1025	1 1..542 544..1025 1025
AAI31779.1	1025	1..731, 733..1023	1 1..731 733..1023 1025
AAP35386.1	173	1..161	1 1..161 1025
BAA89789.1	1025	1..1025	1 1..1025 1025
BAF83906.1	1025	1..28, 30..844, 846..1025	1 1..28 30..844 846..1025 1025

Structured regions (0)

Structure mapping

Domain / Motif regions (10)

Interpro ID	Name	Regions	Map
IPR000759 (PR00419)	Adrenodoxin reductase	189..211, 213..226, 335..349	1 189..211 213..226 335..349 1025
IPR005720 (TIGR01037)	Dihydroorotate dehydrogenase, class 1, core	533..854	1 533..854 1025
IPR009051 (SSF46548)	Alpha-helical ferredoxin	2..198	1 2..198 1025
IPR012135 (PF01180)	Dihydroorotate dehydrogenase, class 1/ 2	534..838	1 534..838 1025
IPR012285 (G3DSA:1.10.1060.10)	Fumarate reductase, C-terminal	27..183	1 27..183 1025
IPR013027 (PF07992)	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	190..484	1 190..484 1025
IPR013785 (G3DSA:3.20.20.70)	Aldolase-type TIM barrel	533..844	1 533..844 1025
IPR016040 (G3DSA:3.40.50.720)	NAD(P)-binding domain	184..532	1 184..532 1025
IPR017896 (PS51379)	4Fe-4S ferredoxin, iron-sulpur binding domain	69..100, 944..976, 978..1007	1 69..100 944..976 978..1007 1025
IPR017900 (PS00198)	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	986..997	1 986..997 1025

Variant regions (0)

Non-synonymous SNPs (6)

dbSNP ID	Residue change	Regions	Map
rs1801158	S → N	535..535	1 535..535 1025
rs1801159	I → L	544..544	1 544..544 1025
rs1801160	V → I	733..733	1 733..733 1025
rs1801266	R → W	236..236	1 236..236 1025
rs1801268	V → F	996..996	1 996..996 1025
rs2297595	M → L	167..167	1 167..167 1025

Interacting regions (1)

Interactants	Ref.	Relation	# of rec.	Region	Map
SMAD7		22 a.a. overlap with IPR009051 (SSF46548). 22 a.a. overlap with IPR012285 (G3DSA:1.10.1060.10). 10 a.a. overlap with IPR017896 (PS51379).	1	65..66, 71..72, 76..76, 79..79, 82..83, 85..85, 87..87, 91..91, 93..93, 111..113, 123..123, 125..126, 130..130, 136..136, 138..138, 140..140	1 65..66 71..72 76..76 79..79 82..83 85..85 87..87 91..91 93..93 111..113 123..123 125..126 130..130 136..136 138..138 140..140 1025

Contacting amino acids (calculated from 3D structures) (0)

Custom regions (0)

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