Gene summary for NP_000101.2

Gene name
dihydropyrimidine dehydrogenase
Symbol
DPYD (Alias: DPYD; DHP; DHPDHASE; DPD; MGC132008; MGC70799)
NCBI GeneID
1806
Organism
Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000101.2 1..1025
1
1..1025
1025

Structured regions (0)

Structure mapping

Domain / Motif regions (10)

Interpro ID Name Regions Map help_icon
IPR000759 (PR00419) Adrenodoxin reductase 189..211, 213..226, 335..349
1
189..211 213..226 335..349
1025
IPR005720 (TIGR01037) Dihydroorotate dehydrogenase, class 1, core 533..854
1
533..854
1025
IPR009051 (SSF46548) Alpha-helical ferredoxin 2..198
1
2..198
1025
IPR012135 (PF01180) Dihydroorotate dehydrogenase, class 1/ 2 534..838
1
534..838
1025
IPR012285 (G3DSA:1.10.1060.10) Fumarate reductase, C-terminal 27..183
1
27..183
1025
IPR013027 (PF07992) FAD-dependent pyridine nucleotide-disulphide oxidoreductase 190..484
1
190..484
1025
IPR013785 (G3DSA:3.20.20.70) Aldolase-type TIM barrel 533..844
1
533..844
1025
IPR016040 (G3DSA:3.40.50.720) NAD(P)-binding domain 184..532
1
184..532
1025
IPR017896 (PS51379) 4Fe-4S ferredoxin, iron-sulpur binding domain 69..100, 944..976, 978..1007
1
69..100 944..976 978..1007
1025
IPR017900 (PS00198) 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 986..997
1
986..997
1025

Variant regions (0)

Non-synonymous SNPs (6)

dbSNP ID Residue change Regions Map help_icon
rs1801158 S → N 535..535
1
535..535
1025
rs1801159 I → L 544..544
1
544..544
1025
rs1801160 V → I 733..733
1
733..733
1025
rs1801266 R → W 236..236
1
236..236
1025
rs1801268 V → F 996..996
1
996..996
1025
rs2297595 M → L 167..167
1
167..167
1025

Interacting regions (1)

Interactants Ref. Relation # of rec. Region Map help_icon
SMAD7 Reference Domain/Motifs
  • 22 a.a. overlap with IPR009051 (SSF46548).
  • 22 a.a. overlap with IPR012285 (G3DSA:1.10.1060.10).
  • 10 a.a. overlap with IPR017896 (PS51379).
SNPs Structured region Variant regions Interacting regions
1 65..66, 71..72, 76..76, 79..79, 82..83, 85..85, 87..87, 91..91, 93..93, 111..113, 123..123, 125..126, 130..130, 136..136, 138..138, 140..140
1
65..66 71..72 76..76 79..79 82..83 85..85 87..87 91..91 93..93 111..113 123..123 125..126 130..130 136..136 138..138 140..140
1025

Contacting amino acids (calculated from 3D structures) (0)

Custom regions (0)

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