Gene summary for NP_000137.2

Gene name
ferritin, light polypeptide
Symbol
FTL (Alias: FTL; MGC71996; NBIA3)
NCBI GeneID
2512
Organism
Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000137.2 1..175
1
1..175
175

Structured regions (10)

PDB ID Chain Regions Mapppp help_icon
2FFX J 5..175
1
5..175
175
2FG4 A 5..175
1
5..175
175
2FG8 A 5..175
1
5..175
175
2FG8 B 5..175
1
5..175
175
2FG8 C 5..175
1
5..175
175
2FG8 D 5..175
1
5..175
175
2FG8 E 5..175
1
5..175
175
2FG8 F 5..175
1
5..175
175
2FG8 G 5..175
1
5..175
175
2FG8 H 5..175
1
5..175
175

Domain / Motif regions (7)

Interpro ID Name Regions Map help_icon
IPR001519 (PTHR11431) Ferritin, N-terminal 1..175
1
1..175
175
IPR008331 (PF00210) Ferritin/Dps protein 15..154
1
15..154
175
IPR009040 (PS50905) Ferritin-like 7..156
1
7..156
175
IPR009078 (SSF47240) Ferritin/ribonucleotide reductase-like 3..173
1
3..173
175
IPR012347 (G3DSA:1.20.1260.10) Ferritin-related 2..175
1
2..175
175
IPR014034 (PS00204) Ferritin, conserved site 123..143
1
123..143
175
IPR014034 (PS00540) Ferritin, conserved site 58..76
1
58..76
175

Variant regions (0)

Non-synonymous SNPs (21)

dbSNP ID Residue change Regions Map help_icon
rs11553195 A → V 45..45
1
45..45
175
rs11553205 S → F 11..11
1
11..11
175
rs11553206 L → P 46..46
1
46..46
175
rs11553209 L → F 112..112
1
112..112
175
rs11553210 A → G 121..121
1
121..121
175
rs11553214 H → N 154..154
1
154..154
175
rs11553216 H → N 149..149
1
149..149
175
rs11553219 A → G 111..111
1
111..111
175
rs11553225 E → Q 65..65
1
65..65
175
rs11553236 L → V 171..171
1
171..171
175
rs11553243 F → I 37..37
1
37..37
175
rs11553257 D → Y 43..43
1
43..43
175
rs11553260 K → R 60..60
1
60..60
175
rs11553262 S → I 50..50
1
50..50
175
rs11553266 D → Y 13..13
1
13..13
175
rs17851422 F → L 80..80
1
80..80
175
rs17851905 G → V 75..75
1
75..75
175
rs17856437 H → R 126..126
1
126..126
175
rs1803578 H → Y 175..175
1
175..175
175
rs1803580 L → F 173..173
1
173..173
175
rs3210196 T → P 94..94
1
94..94
175

Interacting regions (4)

Interactants Ref. Relation # of rec. Region Map help_icon
NFE2L2 Reference Domain/Motifs
  • 130 a.a. overlap with IPR001519 (PTHR11431).
  • 116 a.a. overlap with IPR008331 (PF00210).
  • 124 a.a. overlap with IPR009040 (PS50905).
  • 128 a.a. overlap with IPR009078 (SSF47240).
  • 129 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 8 a.a. overlap with IPR014034 (PS00204).
  • 19 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553205 (Pos=11) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553209 (Pos=112) falls into interacting region.
  • SNP:rs11553210 (Pos=121) falls into interacting region.
  • SNP:rs11553219 (Pos=111) falls into interacting region.
  • SNP:rs11553225 (Pos=65) falls into interacting region.
  • SNP:rs11553243 (Pos=37) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs11553260 (Pos=60) falls into interacting region.
  • SNP:rs11553262 (Pos=50) falls into interacting region.
  • SNP:rs11553266 (Pos=13) falls into interacting region.
  • SNP:rs17851422 (Pos=80) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
  • SNP:rs17856437 (Pos=126) falls into interacting region.
  • SNP:rs3210196 (Pos=94) falls into interacting region.
Structured region
  • 126 a.a. overlap with 2FFX:J.
  • 126 a.a. overlap with 2FG4:A.
  • 126 a.a. overlap with 2FG8:A.
  • 126 a.a. overlap with 2FG8:B.
  • 126 a.a. overlap with 2FG8:C.
  • 126 a.a. overlap with 2FG8:D.
  • 126 a.a. overlap with 2FG8:E.
  • 126 a.a. overlap with 2FG8:F.
  • 126 a.a. overlap with 2FG8:G.
  • 126 a.a. overlap with 2FG8:H.
Variant regions Interacting regions
  • overlap with CEBPE interacting region.
  • overlap with ZSCAN20 interacting region.
  • overlap with TRIM27 interacting region.
1 1..130
1
1..130
175
CEBPE Reference Domain/Motifs
  • 27 a.a. overlap with IPR001519 (PTHR11431).
  • 13 a.a. overlap with IPR008331 (PF00210).
  • 21 a.a. overlap with IPR009040 (PS50905).
  • 25 a.a. overlap with IPR009078 (SSF47240).
  • 26 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553205 (Pos=11) falls into interacting region.
  • SNP:rs11553266 (Pos=13) falls into interacting region.
Structured region
  • 23 a.a. overlap with 2FFX:J.
  • 23 a.a. overlap with 2FG4:A.
  • 23 a.a. overlap with 2FG8:A.
  • 23 a.a. overlap with 2FG8:B.
  • 23 a.a. overlap with 2FG8:C.
  • 23 a.a. overlap with 2FG8:D.
  • 23 a.a. overlap with 2FG8:E.
  • 23 a.a. overlap with 2FG8:F.
  • 23 a.a. overlap with 2FG8:G.
  • 23 a.a. overlap with 2FG8:H.
Variant regions Interacting regions
  • overlap with NFE2L2 interacting region.
  • overlap with ZSCAN20 interacting region.
  • overlap with TRIM27 interacting region.
1 1..27
1
1..27
175
ZSCAN20 Reference Domain/Motifs
  • 57 a.a. overlap with IPR001519 (PTHR11431).
  • 43 a.a. overlap with IPR008331 (PF00210).
  • 51 a.a. overlap with IPR009040 (PS50905).
  • 55 a.a. overlap with IPR009078 (SSF47240).
  • 56 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553205 (Pos=11) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553243 (Pos=37) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs11553262 (Pos=50) falls into interacting region.
  • SNP:rs11553266 (Pos=13) falls into interacting region.
Structured region
  • 53 a.a. overlap with 2FFX:J.
  • 53 a.a. overlap with 2FG4:A.
  • 53 a.a. overlap with 2FG8:A.
  • 53 a.a. overlap with 2FG8:B.
  • 53 a.a. overlap with 2FG8:C.
  • 53 a.a. overlap with 2FG8:D.
  • 53 a.a. overlap with 2FG8:E.
  • 53 a.a. overlap with 2FG8:F.
  • 53 a.a. overlap with 2FG8:G.
  • 53 a.a. overlap with 2FG8:H.
Variant regions Interacting regions
  • overlap with NFE2L2 interacting region.
  • overlap with CEBPE interacting region.
  • overlap with TRIM27 interacting region.
1 1..57
1
1..57
175
TRIM27 Reference Domain/Motifs
  • 94 a.a. overlap with IPR001519 (PTHR11431).
  • 80 a.a. overlap with IPR008331 (PF00210).
  • 88 a.a. overlap with IPR009040 (PS50905).
  • 92 a.a. overlap with IPR009078 (SSF47240).
  • 93 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 19 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553205 (Pos=11) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553225 (Pos=65) falls into interacting region.
  • SNP:rs11553243 (Pos=37) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs11553260 (Pos=60) falls into interacting region.
  • SNP:rs11553262 (Pos=50) falls into interacting region.
  • SNP:rs11553266 (Pos=13) falls into interacting region.
  • SNP:rs17851422 (Pos=80) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
  • SNP:rs3210196 (Pos=94) falls into interacting region.
Structured region
  • 90 a.a. overlap with 2FFX:J.
  • 90 a.a. overlap with 2FG4:A.
  • 90 a.a. overlap with 2FG8:A.
  • 90 a.a. overlap with 2FG8:B.
  • 90 a.a. overlap with 2FG8:C.
  • 90 a.a. overlap with 2FG8:D.
  • 90 a.a. overlap with 2FG8:E.
  • 90 a.a. overlap with 2FG8:F.
  • 90 a.a. overlap with 2FG8:G.
  • 90 a.a. overlap with 2FG8:H.
Variant regions Interacting regions
  • overlap with NFE2L2 interacting region.
  • overlap with CEBPE interacting region.
  • overlap with ZSCAN20 interacting region.
1 1..94
1
1..94
175

Contacting amino acids (calculated from 3D structures) (30)

Interactants Structure Relation Chain Region Map help_icon
FTL 2FG8:C Domain/Motifs
  • 26 a.a. overlap with IPR001519 (PTHR11431).
  • 19 a.a. overlap with IPR008331 (PF00210).
  • 25 a.a. overlap with IPR009040 (PS50905).
  • 26 a.a. overlap with IPR009078 (SSF47240).
  • 26 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 11 a.a. overlap with IPR014034 (PS00204).
  • 6 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553205 (Pos=11) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
  • SNP:rs17856437 (Pos=126) falls into interacting region.
Structured region
  • 26 a.a. overlap with 2FFX:J.
  • 26 a.a. overlap with 2FG4:A.
  • 26 a.a. overlap with 2FG8:A.
  • 26 a.a. overlap with 2FG8:B.
  • 26 a.a. overlap with 2FG8:C.
  • 26 a.a. overlap with 2FG8:D.
  • 26 a.a. overlap with 2FG8:E.
  • 26 a.a. overlap with 2FG8:F.
  • 26 a.a. overlap with 2FG8:G.
  • 26 a.a. overlap with 2FG8:H.
Variant regions
A 6..12, 71..77, 79..79, 125..132, 134..136
1
6..12 71..77 79..79 125..132 134..136
175
FTL 2FG8:D Domain/Motifs
  • 56 a.a. overlap with IPR001519 (PTHR11431).
  • 51 a.a. overlap with IPR008331 (PF00210).
  • 54 a.a. overlap with IPR009040 (PS50905).
  • 56 a.a. overlap with IPR009078 (SSF47240).
  • 56 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 14 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553243 (Pos=37) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs11553260 (Pos=60) falls into interacting region.
  • SNP:rs17851422 (Pos=80) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
Structured region
  • 56 a.a. overlap with 2FFX:J.
  • 56 a.a. overlap with 2FG4:A.
  • 56 a.a. overlap with 2FG8:A.
  • 56 a.a. overlap with 2FG8:B.
  • 56 a.a. overlap with 2FG8:C.
  • 56 a.a. overlap with 2FG8:D.
  • 56 a.a. overlap with 2FG8:E.
  • 56 a.a. overlap with 2FG8:F.
  • 56 a.a. overlap with 2FG8:G.
  • 56 a.a. overlap with 2FG8:H.
Variant regions
A 5..9, 24..25, 28..28, 31..33, 35..46, 52..53, 56..56, 59..60, 63..63, 66..88, 90..93
1
5..9 24..25 28..28 31..33 35..46 52..53 56..56 59..60 63..63 66..88 90..93
175
FTL 2FG8:E Domain/Motifs
  • 23 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 11 a.a. overlap with IPR009040 (PS50905).
  • 23 a.a. overlap with IPR009078 (SSF47240).
  • 23 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 23 a.a. overlap with 2FFX:J.
  • 23 a.a. overlap with 2FG4:A.
  • 23 a.a. overlap with 2FG8:A.
  • 23 a.a. overlap with 2FG8:B.
  • 23 a.a. overlap with 2FG8:C.
  • 23 a.a. overlap with 2FG8:D.
  • 23 a.a. overlap with 2FG8:E.
  • 23 a.a. overlap with 2FG8:F.
  • 23 a.a. overlap with 2FG8:G.
  • 23 a.a. overlap with 2FG8:H.
Variant regions
A 41..49, 95..96, 161..169, 171..173, 177..177
1
41..49 95..96 161..169 171..173 177..177
175
FTL 2FG8:C Domain/Motifs
  • 4 a.a. overlap with IPR001519 (PTHR11431).
  • 4 a.a. overlap with IPR009078 (SSF47240).
  • 4 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 4 a.a. overlap with 2FFX:J.
  • 4 a.a. overlap with 2FG4:A.
  • 4 a.a. overlap with 2FG8:A.
  • 4 a.a. overlap with 2FG8:B.
  • 4 a.a. overlap with 2FG8:C.
  • 4 a.a. overlap with 2FG8:D.
  • 4 a.a. overlap with 2FG8:E.
  • 4 a.a. overlap with 2FG8:F.
  • 4 a.a. overlap with 2FG8:G.
  • 4 a.a. overlap with 2FG8:H.
Variant regions
B 162..162, 165..165, 169..169, 173..173
1
162..162 165..165 169..169 173..173
175
FTL 2FG8:D Domain/Motifs
  • 23 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 11 a.a. overlap with IPR009040 (PS50905).
  • 23 a.a. overlap with IPR009078 (SSF47240).
  • 23 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 23 a.a. overlap with 2FFX:J.
  • 23 a.a. overlap with 2FG4:A.
  • 23 a.a. overlap with 2FG8:A.
  • 23 a.a. overlap with 2FG8:B.
  • 23 a.a. overlap with 2FG8:C.
  • 23 a.a. overlap with 2FG8:D.
  • 23 a.a. overlap with 2FG8:E.
  • 23 a.a. overlap with 2FG8:F.
  • 23 a.a. overlap with 2FG8:G.
  • 23 a.a. overlap with 2FG8:H.
Variant regions
B 41..49, 95..96, 161..169, 171..173, 177..178
1
41..49 95..96 161..169 171..173 177..178
175
FTL 2FG8:G Domain/Motifs
  • 31 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 13 a.a. overlap with IPR009040 (PS50905).
  • 29 a.a. overlap with IPR009078 (SSF47240).
  • 31 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553214 (Pos=154) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs1803578 (Pos=175) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 31 a.a. overlap with 2FFX:J.
  • 31 a.a. overlap with 2FG4:A.
  • 31 a.a. overlap with 2FG8:A.
  • 31 a.a. overlap with 2FG8:B.
  • 31 a.a. overlap with 2FG8:C.
  • 31 a.a. overlap with 2FG8:D.
  • 31 a.a. overlap with 2FG8:E.
  • 31 a.a. overlap with 2FG8:F.
  • 31 a.a. overlap with 2FG8:G.
  • 31 a.a. overlap with 2FG8:H.
Variant regions
B 104..104, 145..163, 165..176
1
104..104 145..163 165..176
175
FTL 2FG8:H Domain/Motifs
  • 57 a.a. overlap with IPR001519 (PTHR11431).
  • 52 a.a. overlap with IPR008331 (PF00210).
  • 55 a.a. overlap with IPR009040 (PS50905).
  • 57 a.a. overlap with IPR009078 (SSF47240).
  • 57 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 14 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553243 (Pos=37) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs11553260 (Pos=60) falls into interacting region.
  • SNP:rs17851422 (Pos=80) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
Structured region
  • 57 a.a. overlap with 2FFX:J.
  • 57 a.a. overlap with 2FG4:A.
  • 57 a.a. overlap with 2FG8:A.
  • 57 a.a. overlap with 2FG8:B.
  • 57 a.a. overlap with 2FG8:C.
  • 57 a.a. overlap with 2FG8:D.
  • 57 a.a. overlap with 2FG8:E.
  • 57 a.a. overlap with 2FG8:F.
  • 57 a.a. overlap with 2FG8:G.
  • 57 a.a. overlap with 2FG8:H.
Variant regions
B 5..9, 24..25, 28..28, 31..33, 35..46, 49..49, 52..53, 56..56, 59..60, 63..63, 66..88, 90..93
1
5..9 24..25 28..28 31..33 35..46 49..49 52..53 56..56 59..60 63..63 66..88 90..93
175
FTL 2FG8:A Domain/Motifs
  • 36 a.a. overlap with IPR001519 (PTHR11431).
  • 36 a.a. overlap with IPR008331 (PF00210).
  • 36 a.a. overlap with IPR009040 (PS50905).
  • 36 a.a. overlap with IPR009078 (SSF47240).
  • 36 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 12 a.a. overlap with IPR014034 (PS00204).
SNPs
  • SNP:rs11553209 (Pos=112) falls into interacting region.
  • SNP:rs11553214 (Pos=154) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553219 (Pos=111) falls into interacting region.
Structured region
  • 36 a.a. overlap with 2FFX:J.
  • 36 a.a. overlap with 2FG4:A.
  • 36 a.a. overlap with 2FG8:A.
  • 36 a.a. overlap with 2FG8:B.
  • 36 a.a. overlap with 2FG8:C.
  • 36 a.a. overlap with 2FG8:D.
  • 36 a.a. overlap with 2FG8:E.
  • 36 a.a. overlap with 2FG8:F.
  • 36 a.a. overlap with 2FG8:G.
  • 36 a.a. overlap with 2FG8:H.
Variant regions
C 101..101, 104..104, 107..115, 118..119, 130..131, 133..135, 137..154
1
101..101 104..104 107..115 118..119 130..131 133..135 137..154
175
FTL 2FG8:B Domain/Motifs
  • 4 a.a. overlap with IPR001519 (PTHR11431).
  • 4 a.a. overlap with IPR009078 (SSF47240).
  • 4 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 4 a.a. overlap with 2FFX:J.
  • 4 a.a. overlap with 2FG4:A.
  • 4 a.a. overlap with 2FG8:A.
  • 4 a.a. overlap with 2FG8:B.
  • 4 a.a. overlap with 2FG8:C.
  • 4 a.a. overlap with 2FG8:D.
  • 4 a.a. overlap with 2FG8:E.
  • 4 a.a. overlap with 2FG8:F.
  • 4 a.a. overlap with 2FG8:G.
  • 4 a.a. overlap with 2FG8:H.
Variant regions
C 162..162, 165..165, 169..169, 173..173
1
162..162 165..165 169..169 173..173
175
FTL 2FG8:D Domain/Motifs
  • 31 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 13 a.a. overlap with IPR009040 (PS50905).
  • 29 a.a. overlap with IPR009078 (SSF47240).
  • 31 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553214 (Pos=154) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs1803578 (Pos=175) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 31 a.a. overlap with 2FFX:J.
  • 31 a.a. overlap with 2FG4:A.
  • 31 a.a. overlap with 2FG8:A.
  • 31 a.a. overlap with 2FG8:B.
  • 31 a.a. overlap with 2FG8:C.
  • 31 a.a. overlap with 2FG8:D.
  • 31 a.a. overlap with 2FG8:E.
  • 31 a.a. overlap with 2FG8:F.
  • 31 a.a. overlap with 2FG8:G.
  • 31 a.a. overlap with 2FG8:H.
Variant regions
C 104..104, 145..163, 165..176
1
104..104 145..163 165..176
175
FTL 2FG8:G Domain/Motifs
  • 24 a.a. overlap with IPR001519 (PTHR11431).
  • 12 a.a. overlap with IPR008331 (PF00210).
  • 12 a.a. overlap with IPR009040 (PS50905).
  • 24 a.a. overlap with IPR009078 (SSF47240).
  • 24 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
  • SNP:rs3210196 (Pos=94) falls into interacting region.
Structured region
  • 24 a.a. overlap with 2FFX:J.
  • 24 a.a. overlap with 2FG4:A.
  • 24 a.a. overlap with 2FG8:A.
  • 24 a.a. overlap with 2FG8:B.
  • 24 a.a. overlap with 2FG8:C.
  • 24 a.a. overlap with 2FG8:D.
  • 24 a.a. overlap with 2FG8:E.
  • 24 a.a. overlap with 2FG8:F.
  • 24 a.a. overlap with 2FG8:G.
  • 24 a.a. overlap with 2FG8:H.
Variant regions
C 41..49, 94..96, 161..169, 171..173, 177..177
1
41..49 94..96 161..169 171..173 177..177
175
FTL 2FG8:A Domain/Motifs
  • 57 a.a. overlap with IPR001519 (PTHR11431).
  • 52 a.a. overlap with IPR008331 (PF00210).
  • 55 a.a. overlap with IPR009040 (PS50905).
  • 57 a.a. overlap with IPR009078 (SSF47240).
  • 57 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 14 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553243 (Pos=37) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs11553260 (Pos=60) falls into interacting region.
  • SNP:rs17851422 (Pos=80) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
Structured region
  • 57 a.a. overlap with 2FFX:J.
  • 57 a.a. overlap with 2FG4:A.
  • 57 a.a. overlap with 2FG8:A.
  • 57 a.a. overlap with 2FG8:B.
  • 57 a.a. overlap with 2FG8:C.
  • 57 a.a. overlap with 2FG8:D.
  • 57 a.a. overlap with 2FG8:E.
  • 57 a.a. overlap with 2FG8:F.
  • 57 a.a. overlap with 2FG8:G.
  • 57 a.a. overlap with 2FG8:H.
Variant regions
D 5..9, 24..25, 28..28, 31..33, 35..47, 52..53, 56..56, 59..60, 63..63, 66..88, 90..93
1
5..9 24..25 28..28 31..33 35..47 52..53 56..56 59..60 63..63 66..88 90..93
175
FTL 2FG8:B Domain/Motifs
  • 30 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 13 a.a. overlap with IPR009040 (PS50905).
  • 28 a.a. overlap with IPR009078 (SSF47240).
  • 30 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553214 (Pos=154) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs1803578 (Pos=175) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 30 a.a. overlap with 2FFX:J.
  • 30 a.a. overlap with 2FG4:A.
  • 30 a.a. overlap with 2FG8:A.
  • 30 a.a. overlap with 2FG8:B.
  • 30 a.a. overlap with 2FG8:C.
  • 30 a.a. overlap with 2FG8:D.
  • 30 a.a. overlap with 2FG8:E.
  • 30 a.a. overlap with 2FG8:F.
  • 30 a.a. overlap with 2FG8:G.
  • 30 a.a. overlap with 2FG8:H.
Variant regions
D 104..104, 145..163, 165..166, 168..176
1
104..104 145..163 165..166 168..176
175
FTL 2FG8:C Domain/Motifs
  • 24 a.a. overlap with IPR001519 (PTHR11431).
  • 12 a.a. overlap with IPR008331 (PF00210).
  • 12 a.a. overlap with IPR009040 (PS50905).
  • 24 a.a. overlap with IPR009078 (SSF47240).
  • 24 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
  • SNP:rs3210196 (Pos=94) falls into interacting region.
Structured region
  • 24 a.a. overlap with 2FFX:J.
  • 24 a.a. overlap with 2FG4:A.
  • 24 a.a. overlap with 2FG8:A.
  • 24 a.a. overlap with 2FG8:B.
  • 24 a.a. overlap with 2FG8:C.
  • 24 a.a. overlap with 2FG8:D.
  • 24 a.a. overlap with 2FG8:E.
  • 24 a.a. overlap with 2FG8:F.
  • 24 a.a. overlap with 2FG8:G.
  • 24 a.a. overlap with 2FG8:H.
Variant regions
D 41..49, 94..96, 161..169, 171..173, 177..177
1
41..49 94..96 161..169 171..173 177..177
175
FTL 2FG8:E Domain/Motifs
  • 26 a.a. overlap with IPR001519 (PTHR11431).
  • 19 a.a. overlap with IPR008331 (PF00210).
  • 24 a.a. overlap with IPR009040 (PS50905).
  • 26 a.a. overlap with IPR009078 (SSF47240).
  • 26 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 11 a.a. overlap with IPR014034 (PS00204).
  • 6 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553205 (Pos=11) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
  • SNP:rs17856437 (Pos=126) falls into interacting region.
Structured region
  • 26 a.a. overlap with 2FFX:J.
  • 26 a.a. overlap with 2FG4:A.
  • 26 a.a. overlap with 2FG8:A.
  • 26 a.a. overlap with 2FG8:B.
  • 26 a.a. overlap with 2FG8:C.
  • 26 a.a. overlap with 2FG8:D.
  • 26 a.a. overlap with 2FG8:E.
  • 26 a.a. overlap with 2FG8:F.
  • 26 a.a. overlap with 2FG8:G.
  • 26 a.a. overlap with 2FG8:H.
Variant regions
D 5..11, 71..77, 79..79, 125..132, 134..136
1
5..11 71..77 79..79 125..132 134..136
175
FTL 2FG8:G Domain/Motifs
  • 4 a.a. overlap with IPR001519 (PTHR11431).
  • 4 a.a. overlap with IPR009078 (SSF47240).
  • 4 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 4 a.a. overlap with 2FFX:J.
  • 4 a.a. overlap with 2FG4:A.
  • 4 a.a. overlap with 2FG8:A.
  • 4 a.a. overlap with 2FG8:B.
  • 4 a.a. overlap with 2FG8:C.
  • 4 a.a. overlap with 2FG8:D.
  • 4 a.a. overlap with 2FG8:E.
  • 4 a.a. overlap with 2FG8:F.
  • 4 a.a. overlap with 2FG8:G.
  • 4 a.a. overlap with 2FG8:H.
Variant regions
D 162..162, 165..165, 169..169, 173..173
1
162..162 165..165 169..169 173..173
175
FTL 2FG8:H Domain/Motifs
  • 36 a.a. overlap with IPR001519 (PTHR11431).
  • 36 a.a. overlap with IPR008331 (PF00210).
  • 36 a.a. overlap with IPR009040 (PS50905).
  • 36 a.a. overlap with IPR009078 (SSF47240).
  • 36 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 12 a.a. overlap with IPR014034 (PS00204).
SNPs
  • SNP:rs11553209 (Pos=112) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553219 (Pos=111) falls into interacting region.
Structured region
  • 36 a.a. overlap with 2FFX:J.
  • 36 a.a. overlap with 2FG4:A.
  • 36 a.a. overlap with 2FG8:A.
  • 36 a.a. overlap with 2FG8:B.
  • 36 a.a. overlap with 2FG8:C.
  • 36 a.a. overlap with 2FG8:D.
  • 36 a.a. overlap with 2FG8:E.
  • 36 a.a. overlap with 2FG8:F.
  • 36 a.a. overlap with 2FG8:G.
  • 36 a.a. overlap with 2FG8:H.
Variant regions
D 101..101, 104..104, 107..115, 118..119, 122..122, 130..131, 133..135, 137..153
1
101..101 104..104 107..115 118..119 122..122 130..131 133..135 137..153
175
FTL 2FG8:A Domain/Motifs
  • 30 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 13 a.a. overlap with IPR009040 (PS50905).
  • 28 a.a. overlap with IPR009078 (SSF47240).
  • 30 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553214 (Pos=154) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs1803578 (Pos=175) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 30 a.a. overlap with 2FFX:J.
  • 30 a.a. overlap with 2FG4:A.
  • 30 a.a. overlap with 2FG8:A.
  • 30 a.a. overlap with 2FG8:B.
  • 30 a.a. overlap with 2FG8:C.
  • 30 a.a. overlap with 2FG8:D.
  • 30 a.a. overlap with 2FG8:E.
  • 30 a.a. overlap with 2FG8:F.
  • 30 a.a. overlap with 2FG8:G.
  • 30 a.a. overlap with 2FG8:H.
Variant regions
E 104..104, 145..163, 165..166, 168..176
1
104..104 145..163 165..166 168..176
175
FTL 2FG8:D Domain/Motifs
  • 38 a.a. overlap with IPR001519 (PTHR11431).
  • 37 a.a. overlap with IPR008331 (PF00210).
  • 38 a.a. overlap with IPR009040 (PS50905).
  • 38 a.a. overlap with IPR009078 (SSF47240).
  • 38 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 12 a.a. overlap with IPR014034 (PS00204).
SNPs
  • SNP:rs11553209 (Pos=112) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553219 (Pos=111) falls into interacting region.
Structured region
  • 38 a.a. overlap with 2FFX:J.
  • 38 a.a. overlap with 2FG4:A.
  • 38 a.a. overlap with 2FG8:A.
  • 38 a.a. overlap with 2FG8:B.
  • 38 a.a. overlap with 2FG8:C.
  • 38 a.a. overlap with 2FG8:D.
  • 38 a.a. overlap with 2FG8:E.
  • 38 a.a. overlap with 2FG8:F.
  • 38 a.a. overlap with 2FG8:G.
  • 38 a.a. overlap with 2FG8:H.
Variant regions
E 101..101, 104..105, 107..115, 118..119, 122..122, 130..131, 133..135, 137..153, 156..156
1
101..101 104..105 107..115 118..119 122..122 130..131 133..135 137..153 156..156
175
FTL 2FG8:F Domain/Motifs
  • 57 a.a. overlap with IPR001519 (PTHR11431).
  • 52 a.a. overlap with IPR008331 (PF00210).
  • 55 a.a. overlap with IPR009040 (PS50905).
  • 57 a.a. overlap with IPR009078 (SSF47240).
  • 57 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 14 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553243 (Pos=37) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs11553260 (Pos=60) falls into interacting region.
  • SNP:rs17851422 (Pos=80) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
Structured region
  • 57 a.a. overlap with 2FFX:J.
  • 57 a.a. overlap with 2FG4:A.
  • 57 a.a. overlap with 2FG8:A.
  • 57 a.a. overlap with 2FG8:B.
  • 57 a.a. overlap with 2FG8:C.
  • 57 a.a. overlap with 2FG8:D.
  • 57 a.a. overlap with 2FG8:E.
  • 57 a.a. overlap with 2FG8:F.
  • 57 a.a. overlap with 2FG8:G.
  • 57 a.a. overlap with 2FG8:H.
Variant regions
E 5..9, 24..25, 28..28, 31..33, 35..46, 49..49, 52..53, 56..56, 59..60, 63..63, 66..88, 90..93
1
5..9 24..25 28..28 31..33 35..46 49..49 52..53 56..56 59..60 63..63 66..88 90..93
175
FTL 2FG8:H Domain/Motifs
  • 28 a.a. overlap with IPR001519 (PTHR11431).
  • 20 a.a. overlap with IPR008331 (PF00210).
  • 26 a.a. overlap with IPR009040 (PS50905).
  • 28 a.a. overlap with IPR009078 (SSF47240).
  • 28 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 11 a.a. overlap with IPR014034 (PS00204).
  • 6 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553205 (Pos=11) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
  • SNP:rs17856437 (Pos=126) falls into interacting region.
Structured region
  • 28 a.a. overlap with 2FFX:J.
  • 28 a.a. overlap with 2FG4:A.
  • 28 a.a. overlap with 2FG8:A.
  • 28 a.a. overlap with 2FG8:B.
  • 28 a.a. overlap with 2FG8:C.
  • 28 a.a. overlap with 2FG8:D.
  • 28 a.a. overlap with 2FG8:E.
  • 28 a.a. overlap with 2FG8:F.
  • 28 a.a. overlap with 2FG8:G.
  • 28 a.a. overlap with 2FG8:H.
Variant regions
E 5..12, 71..77, 79..79, 118..118, 125..132, 134..136
1
5..12 71..77 79..79 118..118 125..132 134..136
175
FTL 2FG8:E Domain/Motifs
  • 58 a.a. overlap with IPR001519 (PTHR11431).
  • 53 a.a. overlap with IPR008331 (PF00210).
  • 56 a.a. overlap with IPR009040 (PS50905).
  • 58 a.a. overlap with IPR009078 (SSF47240).
  • 58 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 14 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553243 (Pos=37) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs11553260 (Pos=60) falls into interacting region.
  • SNP:rs17851422 (Pos=80) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
Structured region
  • 58 a.a. overlap with 2FFX:J.
  • 58 a.a. overlap with 2FG4:A.
  • 58 a.a. overlap with 2FG8:A.
  • 58 a.a. overlap with 2FG8:B.
  • 58 a.a. overlap with 2FG8:C.
  • 58 a.a. overlap with 2FG8:D.
  • 58 a.a. overlap with 2FG8:E.
  • 58 a.a. overlap with 2FG8:F.
  • 58 a.a. overlap with 2FG8:G.
  • 58 a.a. overlap with 2FG8:H.
Variant regions
F 5..9, 24..25, 28..28, 31..33, 35..47, 49..49, 52..53, 56..56, 59..60, 63..63, 66..88, 90..93
1
5..9 24..25 28..28 31..33 35..47 49..49 52..53 56..56 59..60 63..63 66..88 90..93
175
FTL 2FG8:H Domain/Motifs
  • 23 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 11 a.a. overlap with IPR009040 (PS50905).
  • 23 a.a. overlap with IPR009078 (SSF47240).
  • 23 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 23 a.a. overlap with 2FFX:J.
  • 23 a.a. overlap with 2FG4:A.
  • 23 a.a. overlap with 2FG8:A.
  • 23 a.a. overlap with 2FG8:B.
  • 23 a.a. overlap with 2FG8:C.
  • 23 a.a. overlap with 2FG8:D.
  • 23 a.a. overlap with 2FG8:E.
  • 23 a.a. overlap with 2FG8:F.
  • 23 a.a. overlap with 2FG8:G.
  • 23 a.a. overlap with 2FG8:H.
Variant regions
F 41..49, 95..96, 161..169, 171..173, 177..177
1
41..49 95..96 161..169 171..173 177..177
175
FTL 2FG8:B Domain/Motifs
  • 23 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 11 a.a. overlap with IPR009040 (PS50905).
  • 23 a.a. overlap with IPR009078 (SSF47240).
  • 23 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 23 a.a. overlap with 2FFX:J.
  • 23 a.a. overlap with 2FG4:A.
  • 23 a.a. overlap with 2FG8:A.
  • 23 a.a. overlap with 2FG8:B.
  • 23 a.a. overlap with 2FG8:C.
  • 23 a.a. overlap with 2FG8:D.
  • 23 a.a. overlap with 2FG8:E.
  • 23 a.a. overlap with 2FG8:F.
  • 23 a.a. overlap with 2FG8:G.
  • 23 a.a. overlap with 2FG8:H.
Variant regions
G 41..49, 95..96, 161..169, 171..173, 177..177
1
41..49 95..96 161..169 171..173 177..177
175
FTL 2FG8:C Domain/Motifs
  • 31 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 13 a.a. overlap with IPR009040 (PS50905).
  • 29 a.a. overlap with IPR009078 (SSF47240).
  • 31 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553214 (Pos=154) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs1803578 (Pos=175) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 31 a.a. overlap with 2FFX:J.
  • 31 a.a. overlap with 2FG4:A.
  • 31 a.a. overlap with 2FG8:A.
  • 31 a.a. overlap with 2FG8:B.
  • 31 a.a. overlap with 2FG8:C.
  • 31 a.a. overlap with 2FG8:D.
  • 31 a.a. overlap with 2FG8:E.
  • 31 a.a. overlap with 2FG8:F.
  • 31 a.a. overlap with 2FG8:G.
  • 31 a.a. overlap with 2FG8:H.
Variant regions
G 104..104, 145..163, 165..176
1
104..104 145..163 165..176
175
FTL 2FG8:D Domain/Motifs
  • 4 a.a. overlap with IPR001519 (PTHR11431).
  • 4 a.a. overlap with IPR009078 (SSF47240).
  • 4 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 4 a.a. overlap with 2FFX:J.
  • 4 a.a. overlap with 2FG4:A.
  • 4 a.a. overlap with 2FG8:A.
  • 4 a.a. overlap with 2FG8:B.
  • 4 a.a. overlap with 2FG8:C.
  • 4 a.a. overlap with 2FG8:D.
  • 4 a.a. overlap with 2FG8:E.
  • 4 a.a. overlap with 2FG8:F.
  • 4 a.a. overlap with 2FG8:G.
  • 4 a.a. overlap with 2FG8:H.
Variant regions
G 162..162, 165..165, 169..169, 173..173
1
162..162 165..165 169..169 173..173
175
FTL 2FG8:B Domain/Motifs
  • 58 a.a. overlap with IPR001519 (PTHR11431).
  • 53 a.a. overlap with IPR008331 (PF00210).
  • 56 a.a. overlap with IPR009040 (PS50905).
  • 58 a.a. overlap with IPR009078 (SSF47240).
  • 58 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 14 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553195 (Pos=45) falls into interacting region.
  • SNP:rs11553206 (Pos=46) falls into interacting region.
  • SNP:rs11553243 (Pos=37) falls into interacting region.
  • SNP:rs11553257 (Pos=43) falls into interacting region.
  • SNP:rs11553260 (Pos=60) falls into interacting region.
  • SNP:rs17851422 (Pos=80) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
Structured region
  • 58 a.a. overlap with 2FFX:J.
  • 58 a.a. overlap with 2FG4:A.
  • 58 a.a. overlap with 2FG8:A.
  • 58 a.a. overlap with 2FG8:B.
  • 58 a.a. overlap with 2FG8:C.
  • 58 a.a. overlap with 2FG8:D.
  • 58 a.a. overlap with 2FG8:E.
  • 58 a.a. overlap with 2FG8:F.
  • 58 a.a. overlap with 2FG8:G.
  • 58 a.a. overlap with 2FG8:H.
Variant regions
H 5..9, 24..25, 28..28, 31..47, 52..53, 56..56, 59..60, 63..63, 66..88, 90..93
1
5..9 24..25 28..28 31..47 52..53 56..56 59..60 63..63 66..88 90..93
175
FTL 2FG8:D Domain/Motifs
  • 26 a.a. overlap with IPR001519 (PTHR11431).
  • 19 a.a. overlap with IPR008331 (PF00210).
  • 25 a.a. overlap with IPR009040 (PS50905).
  • 26 a.a. overlap with IPR009078 (SSF47240).
  • 26 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 11 a.a. overlap with IPR014034 (PS00204).
  • 6 a.a. overlap with IPR014034 (PS00540).
SNPs
  • SNP:rs11553205 (Pos=11) falls into interacting region.
  • SNP:rs17851905 (Pos=75) falls into interacting region.
  • SNP:rs17856437 (Pos=126) falls into interacting region.
Structured region
  • 26 a.a. overlap with 2FFX:J.
  • 26 a.a. overlap with 2FG4:A.
  • 26 a.a. overlap with 2FG8:A.
  • 26 a.a. overlap with 2FG8:B.
  • 26 a.a. overlap with 2FG8:C.
  • 26 a.a. overlap with 2FG8:D.
  • 26 a.a. overlap with 2FG8:E.
  • 26 a.a. overlap with 2FG8:F.
  • 26 a.a. overlap with 2FG8:G.
  • 26 a.a. overlap with 2FG8:H.
Variant regions
H 6..12, 71..77, 79..79, 125..132, 134..136
1
6..12 71..77 79..79 125..132 134..136
175
FTL 2FG8:E Domain/Motifs
  • 38 a.a. overlap with IPR001519 (PTHR11431).
  • 38 a.a. overlap with IPR008331 (PF00210).
  • 38 a.a. overlap with IPR009040 (PS50905).
  • 38 a.a. overlap with IPR009078 (SSF47240).
  • 38 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
  • 12 a.a. overlap with IPR014034 (PS00204).
SNPs
  • SNP:rs11553209 (Pos=112) falls into interacting region.
  • SNP:rs11553214 (Pos=154) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553219 (Pos=111) falls into interacting region.
Structured region
  • 38 a.a. overlap with 2FFX:J.
  • 38 a.a. overlap with 2FG4:A.
  • 38 a.a. overlap with 2FG8:A.
  • 38 a.a. overlap with 2FG8:B.
  • 38 a.a. overlap with 2FG8:C.
  • 38 a.a. overlap with 2FG8:D.
  • 38 a.a. overlap with 2FG8:E.
  • 38 a.a. overlap with 2FG8:F.
  • 38 a.a. overlap with 2FG8:G.
  • 38 a.a. overlap with 2FG8:H.
Variant regions
H 101..101, 104..104, 107..116, 118..119, 122..122, 130..131, 133..135, 137..154
1
101..101 104..104 107..116 118..119 122..122 130..131 133..135 137..154
175
FTL 2FG8:F Domain/Motifs
  • 31 a.a. overlap with IPR001519 (PTHR11431).
  • 11 a.a. overlap with IPR008331 (PF00210).
  • 13 a.a. overlap with IPR009040 (PS50905).
  • 29 a.a. overlap with IPR009078 (SSF47240).
  • 31 a.a. overlap with IPR012347 (G3DSA:1.20.1260.10).
SNPs
  • SNP:rs11553214 (Pos=154) falls into interacting region.
  • SNP:rs11553216 (Pos=149) falls into interacting region.
  • SNP:rs11553236 (Pos=171) falls into interacting region.
  • SNP:rs1803578 (Pos=175) falls into interacting region.
  • SNP:rs1803580 (Pos=173) falls into interacting region.
Structured region
  • 31 a.a. overlap with 2FFX:J.
  • 31 a.a. overlap with 2FG4:A.
  • 31 a.a. overlap with 2FG8:A.
  • 31 a.a. overlap with 2FG8:B.
  • 31 a.a. overlap with 2FG8:C.
  • 31 a.a. overlap with 2FG8:D.
  • 31 a.a. overlap with 2FG8:E.
  • 31 a.a. overlap with 2FG8:F.
  • 31 a.a. overlap with 2FG8:G.
  • 31 a.a. overlap with 2FG8:H.
Variant regions
H 104..104, 145..163, 165..176
1
104..104 145..163 165..176
175

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