Gene summary for NP_000808.2

Gene name
glutamate decarboxylase 1 (brain, 67kDa)
Symbol
GAD1 (Alias: GAD1; FLJ45882; GAD; SCP)
NCBI GeneID
2571
Organism
Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000808.2 1..594
1
1..594
594

Structured regions (2)

PDB ID Chain Regions Mapppp help_icon
2OKJ A 93..593
1
93..593
594
2OKJ B 93..594
1
93..594
594

Domain / Motif regions (5)

Interpro ID Name Regions Map help_icon
IPR002129 (PTHR11999) Pyridoxal phosphate-dependent decarboxylase 319..594
1
319..594
594
IPR002129 (PF00282) Pyridoxal phosphate-dependent decarboxylase 151..517
1
151..517
594
IPR015421 (G3DSA:3.40.640.10) Pyridoxal phosphate-dependent transferase, major region, subdomain 1 193..481
1
193..481
594
IPR015424 (SSF53383) Pyridoxal phosphate-dependent transferase, major domain 108..594
1
108..594
594
IPR021115 (PS00392) Pyridoxal-phosphate binding site 398..419
1
398..419
594

Variant regions (0)

Non-synonymous SNPs (4)

dbSNP ID Residue change Regions Map help_icon
rs1049731 A → P 18..18
1
18..18
594
rs1049736 F → L 566..566
1
566..566
594
rs769402 R → Q 533..533
1
533..533
594
rs769403 V → G 475..475
1
475..475
594

Interacting regions (1)

Interactants Ref. Relation # of rec. Region Map help_icon
JUN Reference Domain/Motifs
  • 16 a.a. overlap with IPR002129 (PF00282).
  • 16 a.a. overlap with IPR015421 (G3DSA:3.40.640.10).
  • 16 a.a. overlap with IPR015424 (SSF53383).
SNPs Structured region
  • 16 a.a. overlap with 2OKJ:A.
  • 16 a.a. overlap with 2OKJ:B.
Variant regions Interacting regions
1 237..252
1
237..252
594

Contacting amino acids (calculated from 3D structures) (2)

Interactants Structure Relation Chain Region Map help_icon
GAD1 2OKJ:B Domain/Motifs
  • 82 a.a. overlap with IPR002129 (PTHR11999).
  • 175 a.a. overlap with IPR002129 (PF00282).
  • 139 a.a. overlap with IPR015421 (G3DSA:3.40.640.10).
  • 234 a.a. overlap with IPR015424 (SSF53383).
  • 7 a.a. overlap with IPR021115 (PS00392).
SNPs
  • SNP:rs769403 (Pos=475) falls into interacting region.
Structured region
  • 241 a.a. overlap with 2OKJ:A.
  • 241 a.a. overlap with 2OKJ:B.
Variant regions
A 99..101, 103..106, 109..118, 120..134, 139..149, 154..165, 167..183, 185..185, 187..187, 189..225, 227..233, 249..254, 257..257, 261..261, 264..264, 270..282, 290..308, 348..349, 404..405, 408..412, 427..446, 449..476, 478..478, 482..482, 536..537, 540..541, 543..545, 547..548, 553..559, 564..564, 567..567, 572..576
1
99..101 103..106 109..118 120..134 139..149 154..165 167..183 185..185 187..187 189..225 227..233 249..254 257..257 261..261 264..264 270..282 290..308 348..349 404..405 408..412 427..446 449..476 478..478 482..482 536..537 540..541 543..545 547..548 553..559 564..564 567..567 572..576
594
GAD1 2OKJ:A Domain/Motifs
  • 82 a.a. overlap with IPR002129 (PTHR11999).
  • 175 a.a. overlap with IPR002129 (PF00282).
  • 140 a.a. overlap with IPR015421 (G3DSA:3.40.640.10).
  • 234 a.a. overlap with IPR015424 (SSF53383).
  • 7 a.a. overlap with IPR021115 (PS00392).
SNPs
  • SNP:rs769403 (Pos=475) falls into interacting region.
Structured region
  • 241 a.a. overlap with 2OKJ:A.
  • 241 a.a. overlap with 2OKJ:B.
Variant regions
B 99..101, 103..106, 110..118, 120..134, 139..149, 154..165, 167..183, 185..185, 187..187, 189..212, 214..225, 227..233, 236..236, 249..254, 257..258, 261..261, 264..264, 270..281, 289..308, 348..349, 384..384, 404..405, 408..412, 427..444, 446..446, 449..476, 478..478, 536..537, 539..541, 543..545, 547..548, 553..559, 564..564, 567..567, 572..576
1
99..101 103..106 110..118 120..134 139..149 154..165 167..183 185..185 187..187 189..212 214..225 227..233 236..236 249..254 257..258 261..261 264..264 270..281 289..308 348..349 384..384 404..405 408..412 427..444 446..446 449..476 478..478 536..537 539..541 543..545 547..548 553..559 564..564 567..567 572..576
594

Custom regions (0)

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