Gene summary for NP_000866.1

Gene name
insulin-like growth factor 1 receptor
Symbol
IGF1R (Alias: IGF1R; CD221; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216)
NCBI GeneID
3480
Organism
Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000866.1 1..1367
1
1..1367
1367

Structured regions (5)

PDB ID Chain Regions Mapppp help_icon
1JQH A 984..1286
1
984..1286
1367
1K3A A 958..1256
1
958..1256
1367
1M7N A 979..1283
1
979..1283
1367
1P4O A 948..1255
1
948..1255
1367
2OJ9 A 954..1256
1
954..1256
1367

Domain / Motif regions (18)

Interpro ID Name Regions Map help_icon
IPR000494 (PF01030) EGF receptor, L domain 51..160, 352..462
1
51..160 352..462
1367
IPR000719 (PS50011) Protein kinase, catalytic domain 999..1274
1
999..1274
1367
IPR001245 (PF07714) Serine-threonine/tyrosine-protein kinase 999..1265
1
999..1265
1367
IPR002011 (PS00239) Tyrosine-protein kinase, receptor class II, conserved site 1159..1167
1
1159..1167
1367
IPR003961 (PF00041) Fibronectin, type III 835..916
1
835..916
1367
IPR003961 (PS50853) Fibronectin, type III 488..606, 611..689, 831..926
1
488..606 611..689 831..926
1367
IPR003961 (SM00060) Fibronectin, type III 489..592, 611..814, 832..914
1
489..592 611..814 832..914
1367
IPR006211 (PF00757) Furin-like cysteine-rich domain 176..333
1
176..333
1367
IPR006212 (SM00261) Furin-like repeat 227..270
1
227..270
1367
IPR008266 (PS00109) Tyrosine-protein kinase, active site 1131..1143
1
1131..1143
1367
IPR008957 (G3DSA:2.60.40.30) Fibronectin, type III-like fold 829..927
1
829..927
1367
IPR009030 (SSF57184) Growth factor, receptor 180..329
1
180..329
1367
IPR011009 (SSF56112) Protein kinase-like domain 984..1286
1
984..1286
1367
IPR016246 (PIRSF000620) Tyrosine-protein kinase, insulin-like receptor 1..1367
1
1..1367
1367
IPR017441 (PS00107) Protein kinase, ATP binding site 1005..1033
1
1005..1033
1367
IPR020635 (SM00219) Tyrosine-protein kinase, catalytic domain 999..1266
1
999..1266
1367
IPR020685 (PTHR23256) Tyrosine-protein kinase 141..1341
1
141..1341
1367
IPR020714 (PTHR23256:SF178) Tyrosine-protein kinase, insulin-like growth factor receptor 141..1341
1
141..1341
1367

Variant regions (0)

Non-synonymous SNPs (26)

dbSNP ID Residue change Regions Map help_icon
rs33958176 R → Q 512..512
1
512..512
1367
rs34061581 H → R 809..809
1
809..809
1367
rs34102392 A → T 1339..1339
1
1339..1339
1367
rs34516635 R → H 438..438
1
438..438
1367
rs35224135 A → T 829..829
1
829..829
1367
rs35385418 R → S 135..135
1
135..135
1367
rs45445894 V → M 389..389
1
389..389
1367
rs45451896 R → L 660..660
1
660..660
1367
rs45475702 V → I 1304..1304
1
1304..1304
1367
rs45493995 S → I 966..966
1
966..966
1367
rs45504297 L → P 1242..1242
1
1242..1242
1367
rs45512296 R → H 1247..1247
1
1247..1247
1367
rs45522834 T → I 763..763
1
763..763
1367
rs45524940 T → A 576..576
1
576..576
1367
rs45526336 E → K 1284..1284
1
1284..1284
1367
rs45553041 R → H 606..606
1
606..606
1367
rs45578132 V → A 881..881
1
881..881
1367
rs45597432 I → T 323..323
1
323..323
1367
rs45611935 N → S 858..858
1
858..858
1367
rs56248469 R → H 596..596
1
596..596
1367
rs61731172 R → Q 651..651
1
651..651
1367
rs61740868 R → C 1247..1247
1
1247..1247
1367
rs61740877 V → I 493..493
1
493..493
1367
rs70958396 A → T 761..761
1
761..761
1367
rs70958401 R → W 223..223
1
223..223
1367
rs79221540 S → P 498..498
1
498..498
1367

Interacting regions (1)

Interactants Ref. Relation # of rec. Region Map help_icon
MDM2 Reference Domain/Motifs
  • 18 a.a. overlap with IPR003961 (PF00041).
  • 18 a.a. overlap with IPR003961 (PS50853).
  • 18 a.a. overlap with IPR003961 (SM00060).
  • 18 a.a. overlap with IPR008957 (G3DSA:2.60.40.30).
  • 18 a.a. overlap with IPR016246 (PIRSF000620).
  • 18 a.a. overlap with IPR020685 (PTHR23256).
  • 18 a.a. overlap with IPR020714 (PTHR23256:SF178).
SNPs
  • SNP:rs45578132 (Pos=881) falls into interacting region.
Structured region Variant regions Interacting regions
1 873..890
1
873..890
1367

Contacting amino acids (calculated from 3D structures) (1)

Interactants Structure Relation Chain Region Map help_icon
IRS1 1K3A:B Domain/Motifs
  • 35 a.a. overlap with IPR000719 (PS50011).
  • 35 a.a. overlap with IPR001245 (PF07714).
  • 1 a.a. overlap with IPR002011 (PS00239).
  • 7 a.a. overlap with IPR008266 (PS00109).
  • 35 a.a. overlap with IPR011009 (SSF56112).
  • 35 a.a. overlap with IPR016246 (PIRSF000620).
  • 35 a.a. overlap with IPR020635 (SM00219).
  • 35 a.a. overlap with IPR020685 (PTHR23256).
  • 35 a.a. overlap with IPR020714 (PTHR23256:SF178).
SNPs Structured region
  • 35 a.a. overlap with 1JQH:A.
  • 35 a.a. overlap with 1K3A:A.
  • 35 a.a. overlap with 1M7N:A.
  • 35 a.a. overlap with 1P4O:A.
  • 35 a.a. overlap with 2OJ9:A.
Variant regions
A 1058..1058, 1104..1105, 1107..1107, 1109..1110, 1123..1123, 1126..1126, 1137..1149, 1152..1159, 1181..1182, 1188..1189, 1192..1192, 1196..1196
1
1058..1058 1104..1105 1107..1107 1109..1110 1123..1123 1126..1126 1137..1149 1152..1159 1181..1182 1188..1189 1192..1192 1196..1196
1367

Custom regions (0)

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