Gene summary for NP_000928.1

Gene name
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Symbol
POLR2A (Alias: POLR2A; MGC75453; POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1)
NCBI GeneID
5430
Organism
Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000928.1 1..1970
1
1..1970
1970

Structured regions (2)

PDB ID Chain Regions Mapppp help_icon
2GHQ C 171..175
1
171..175
1970
2GHT C 171..175
1
171..175
1970

Domain / Motif regions (12)

Interpro ID Name Regions Map help_icon
IPR000684 (PS00115) RNA polymerase II, heptapeptide repeat, eukaryotic 1593..1599, 1615..1621, 1622..1628, 1629..1635, 1636..1642, 1643..1649, 1650..1656, 1657..1663, 1664..1670, 1671..1677, 1678..1684, 1685..1691, 1692..1698, 1699..1705, 1706..1712, 1713..1719, 1720..1726, 1727..1733, 1734..1740, 1741..1747, 1748..1754, 1755..1761, 1762..1768, 1769..1775, 1776..1782, 1783..1789, 1790..1796, 1797..1803, 1818..1824, 1825..1831, 1839..1845, 1853..1859, 1860..1866, 1867..1873, 1874..1880, 1888..1894, 1902..1908, 1909..1915, 1916..1922, 1923..1929, 1930..1936, 1947..1953
1
1593..1599 1615..1621 1622..1628 1629..1635 1636..1642 1643..1649 1650..1656 1657..1663 1664..1670 1671..1677 1678..1684 1685..1691 1692..1698 1699..1705 1706..1712 1713..1719 1720..1726 1727..1733 1734..1740 1741..1747 1748..1754 1755..1761 1762..1768 1769..1775 1776..1782 1783..1789 1790..1796 1797..1803 1818..1824 1825..1831 1839..1845 1853..1859 1860..1866 1867..1873 1874..1880 1888..1894 1902..1908 1909..1915 1916..1922 1923..1929 1930..1936 1947..1953
1970
IPR000722 (G3DSA:2.40.40.30) RNA polymerase, alpha subunit 431..523
1
431..523
1970
IPR000722 (PF00623) RNA polymerase, alpha subunit 356..521
1
356..521
1970
IPR006592 (SM00663) RNA polymerase, N-terminal 246..549
1
246..549
1970
IPR007066 (PF04983) RNA polymerase Rpb1, domain 3 525..691
1
525..691
1970
IPR007073 (G3DSA:3.30.1360.90) RNA polymerase Rpb1, domain 7 1165..1300
1
1165..1300
1970
IPR007073 (PF04990) RNA polymerase Rpb1, domain 7 1164..1299
1
1164..1299
1970
IPR007075 (PF04992) RNA polymerase Rpb1, domain 6 896..1079
1
896..1079
1970
IPR007080 (G3DSA:3.90.1120.10) RNA polymerase Rpb1, domain 1 14..357
1
14..357
1970
IPR007080 (PF04997) RNA polymerase Rpb1, domain 1 16..354
1
16..354
1970
IPR007081 (PF04998) RNA polymerase Rpb1, domain 5 830..1424
1
830..1424
1970
IPR007083 (PF05000) RNA polymerase Rpb1, domain 4 718..823
1
718..823
1970

Variant regions (0)

Non-synonymous SNPs (3)

dbSNP ID Residue change Regions Map help_icon
rs2229198 R → C 293..293
1
293..293
1970
rs3198998 T → I 1610..1610
1
1610..1610
1970
rs4344809 T → A 1836..1836
1
1836..1836
1970

Interacting regions (1)

Interactants Ref. Relation # of rec. Region Map help_icon
POLR2H Reference Domain/Motifs
  • 24 a.a. overlap with IPR006592 (SM00663).
  • 62 a.a. overlap with IPR007066 (PF04983).
SNPs Structured region Variant regions Interacting regions
1 526..587
1
526..587
1970

Contacting amino acids (calculated from 3D structures) (2)

Interactants Structure Relation Chain Region Map help_icon
CTDSP1 2GHQ:A Domain/Motifs
  • 5 a.a. overlap with IPR007080 (G3DSA:3.90.1120.10).
  • 5 a.a. overlap with IPR007080 (PF04997).
SNPs Structured region
  • 5 a.a. overlap with 2GHQ:C.
  • 5 a.a. overlap with 2GHT:C.
Variant regions
C 171..175
1
171..175
1970
CTDSP1 2GHT:A Domain/Motifs
  • 5 a.a. overlap with IPR007080 (G3DSA:3.90.1120.10).
  • 5 a.a. overlap with IPR007080 (PF04997).
SNPs Structured region
  • 5 a.a. overlap with 2GHQ:C.
  • 5 a.a. overlap with 2GHT:C.
Variant regions
C 171..175
1
171..175
1970

Custom regions (0)

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