Gene summary for NP_000935.1

Gene name
protein phosphatase 3, catalytic subunit, alpha isozyme
Symbol
PPP3CA (Alias: PPP3CA; CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B)
NCBI GeneID
5530
Organism
Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_000935.1 1..521
1
1..521
521

Structured regions (5)

PDB ID Chain Regions Mapppp help_icon
1AUI A 14..486
1
14..486
521
1M63 A 1..372
1
1..372
521
1MF8 A 20..371
1
20..371
521
2P6B A 14..370
1
14..370
521
2P6B C 14..370
1
14..370
521

Domain / Motif regions (5)

Interpro ID Name Regions Map help_icon
IPR004843 (PF00149) Metallophosphoesterase 84..284
1
84..284
521
IPR006186 (PTHR11668) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 45..518
1
45..518
521
IPR006186 (PR00114) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 84..111, 113..140, 146..170, 180..206, 209..236, 273..293, 301..317
1
84..111 113..140 146..170 180..206 209..236 273..293 301..317
521
IPR006186 (PS00125) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 147..152
1
147..152
521
IPR006186 (SM00156) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 56..347
1
56..347
521

Variant regions (4)

Protein ID Type Regions Map help_icon
AAH25714.1 missing in related sequence 448..457
1
448..457
521
ABW74484.1 missing in related sequence 319..360
1
319..360
521
ABW74484.1 missing in related sequence 448..457
1
448..457
521
ABW74485.1 missing in related sequence 87..318
1
87..318
521

Non-synonymous SNPs (1)

dbSNP ID Residue change Regions Map help_icon
rs4146577 K → Q 319..319
1
319..319
521

Interacting regions (2)

Interactants Ref. Relation # of rec. Region Map help_icon
NR3C1 Reference Domain/Motifs
  • 12 a.a. overlap with IPR006186 (PTHR11668).
SNPs Structured region
  • 12 a.a. overlap with 1AUI:A.
  • 1 a.a. overlap with 1M63:A.
Variant regions Interacting regions
1 372..383
1
372..383
521
RXRB Reference Domain/Motifs
  • 33 a.a. overlap with IPR006186 (PTHR11668).
SNPs Structured region
  • 33 a.a. overlap with 1AUI:A.
Variant regions Interacting regions
1 392..424
1
392..424
521

Contacting amino acids (calculated from 3D structures) (4)

Interactants Structure Relation Chain Region Map help_icon
PPP3R1 2P6B:B Domain/Motifs
  • 5 a.a. overlap with IPR004843 (PF00149).
  • 38 a.a. overlap with IPR006186 (PTHR11668).
  • 5 a.a. overlap with IPR006186 (PR00114).
  • 12 a.a. overlap with IPR006186 (SM00156).
SNPs Structured region
  • 53 a.a. overlap with 1AUI:A.
  • 53 a.a. overlap with 1M63:A.
  • 47 a.a. overlap with 1MF8:A.
  • 53 a.a. overlap with 2P6B:A.
  • 53 a.a. overlap with 2P6B:C.
Variant regions
  • 20 a.a. overlap with variant regions in ABW74484.1.
  • 5 a.a. overlap with variant regions in ABW74485.1.
A 14..28, 52..53, 55..55, 125..125, 167..170, 339..343, 346..370
1
14..28 52..53 55..55 125..125 167..170 339..343 346..370
521
PPP3CA 2P6B:C Domain/Motifs
  • 18 a.a. overlap with IPR006186 (PTHR11668).
  • 3 a.a. overlap with IPR006186 (PR00114).
  • 18 a.a. overlap with IPR006186 (SM00156).
SNPs Structured region
  • 18 a.a. overlap with 1AUI:A.
  • 18 a.a. overlap with 1M63:A.
  • 18 a.a. overlap with 1MF8:A.
  • 18 a.a. overlap with 2P6B:A.
  • 18 a.a. overlap with 2P6B:C.
Variant regions
  • 10 a.a. overlap with variant regions in ABW74484.1.
  • 8 a.a. overlap with variant regions in ABW74485.1.
A 288..288, 290..290, 293..293, 297..300, 318..318, 324..333
1
288..288 290..290 293..293 297..300 318..318 324..333
521
PPP3CA 2P6B:A Domain/Motifs
  • 1 a.a. overlap with IPR004843 (PF00149).
  • 19 a.a. overlap with IPR006186 (PTHR11668).
  • 4 a.a. overlap with IPR006186 (PR00114).
  • 19 a.a. overlap with IPR006186 (SM00156).
SNPs Structured region
  • 19 a.a. overlap with 1AUI:A.
  • 19 a.a. overlap with 1M63:A.
  • 19 a.a. overlap with 1MF8:A.
  • 19 a.a. overlap with 2P6B:A.
  • 19 a.a. overlap with 2P6B:C.
Variant regions
  • 8 a.a. overlap with variant regions in ABW74484.1.
  • 11 a.a. overlap with variant regions in ABW74485.1.
C 275..275, 288..288, 290..290, 293..300, 325..332
1
275..275 288..288 290..290 293..300 325..332
521
PPP3R1 2P6B:D Domain/Motifs
  • 3 a.a. overlap with IPR004843 (PF00149).
  • 36 a.a. overlap with IPR006186 (PTHR11668).
  • 3 a.a. overlap with IPR006186 (PR00114).
  • 10 a.a. overlap with IPR006186 (SM00156).
SNPs Structured region
  • 51 a.a. overlap with 1AUI:A.
  • 51 a.a. overlap with 1M63:A.
  • 45 a.a. overlap with 1MF8:A.
  • 51 a.a. overlap with 2P6B:A.
  • 51 a.a. overlap with 2P6B:C.
Variant regions
  • 20 a.a. overlap with variant regions in ABW74484.1.
  • 3 a.a. overlap with variant regions in ABW74485.1.
C 14..28, 52..53, 55..55, 125..125, 168..169, 339..343, 346..370
1
14..28 52..53 55..55 125..125 168..169 339..343 346..370
521

Custom regions (0)

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