Gene summary for NP_002219.1

Gene name
jun oncogene
Symbol
JUN (Alias: JUN; AP-1; AP1; c-Jun)
NCBI GeneID
3725
Organism
Homo sapiens

Protein sequences and regions

Representative sequence

RefSeq ID Region Map help_icon
NP_002219.1 1..331
1
1..331
331

Structured regions (6)

PDB ID Chain Regions Mapppp help_icon
1A02 J 267..318
1
267..318
331
1FOS F 257..268, 270..313
1
257..268 270..313
331
1JNM A 254..309
1
254..309
331
1JNM B 254..310
1
254..310
331
1S9K E 267..318
1
267..318
331
1T2K C 253..314
1
253..314
331

Domain / Motif regions (8)

Interpro ID Name Regions Map help_icon
IPR002112 (PR00043) Transcription factor Jun 239..259, 261..277, 279..291, 294..308, 308..323
1
239..259 261..277 279..291 294..308 308..323
331
IPR004827 (PS00036) Basic-leucine zipper (bZIP) transcription factor 257..272
1
257..272
331
IPR004827 (PS50217) Basic-leucine zipper (bZIP) transcription factor 252..315
1
252..315
331
IPR004827 (SM00338) Basic-leucine zipper (bZIP) transcription factor 250..314
1
250..314
331
IPR005643 (PF03957) Jun-like transcription factor 5..241
1
5..241
331
IPR008917 (SSF47454) Eukaryotic transcription factor, Skn-1-like, DNA-binding 221..277
1
221..277
331
IPR011616 (PF00170) bZIP transcription factor, bZIP-1 250..313
1
250..313
331
IPR015558 (PTHR11462:SF8) c-Jun Transcription Factor 2..329
1
2..329
331

Variant regions (0)

Non-synonymous SNPs (1)

dbSNP ID Residue change Regions Map help_icon
rs9989 T → M 298..298
1
298..298
331

Interacting regions (29)

Interactants Ref. Relation # of rec. Region Map help_icon
MDM2 Reference Domain/Motifs
  • 76 a.a. overlap with IPR002112 (PR00043).
  • 16 a.a. overlap with IPR004827 (PS00036).
  • 64 a.a. overlap with IPR004827 (PS50217).
  • 65 a.a. overlap with IPR004827 (SM00338).
  • 33 a.a. overlap with IPR008917 (SSF47454).
  • 64 a.a. overlap with IPR011616 (PF00170).
  • 82 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 52 a.a. overlap with 1A02:J.
  • 56 a.a. overlap with 1FOS:F.
  • 56 a.a. overlap with 1JNM:A.
  • 57 a.a. overlap with 1JNM:B.
  • 52 a.a. overlap with 1S9K:E.
  • 62 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 245..326
1
245..326
331
FOS Reference Domain/Motifs
  • 64 a.a. overlap with IPR002112 (PR00043).
  • 16 a.a. overlap with IPR004827 (PS00036).
  • 59 a.a. overlap with IPR004827 (PS50217).
  • 58 a.a. overlap with IPR004827 (SM00338).
  • 21 a.a. overlap with IPR008917 (SSF47454).
  • 57 a.a. overlap with IPR011616 (PF00170).
  • 70 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 52 a.a. overlap with 1A02:J.
  • 56 a.a. overlap with 1FOS:F.
  • 53 a.a. overlap with 1JNM:A.
  • 54 a.a. overlap with 1JNM:B.
  • 52 a.a. overlap with 1S9K:E.
  • 58 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
3 257..326
1
257..326
331
ETS1 Reference Domain/Motifs
  • 63 a.a. overlap with IPR002112 (PR00043).
  • 15 a.a. overlap with IPR004827 (PS00036).
  • 58 a.a. overlap with IPR004827 (PS50217).
  • 57 a.a. overlap with IPR004827 (SM00338).
  • 20 a.a. overlap with IPR008917 (SSF47454).
  • 56 a.a. overlap with IPR011616 (PF00170).
  • 68 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 52 a.a. overlap with 1A02:J.
  • 55 a.a. overlap with 1FOS:F.
  • 52 a.a. overlap with 1JNM:A.
  • 53 a.a. overlap with 1JNM:B.
  • 52 a.a. overlap with 1S9K:E.
  • 57 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 258..325
1
258..325
331
SMAD2 Reference Domain/Motifs
  • 51 a.a. overlap with IPR002112 (PR00043).
  • 14 a.a. overlap with IPR004827 (PS00036).
  • 54 a.a. overlap with IPR004827 (PS50217).
  • 54 a.a. overlap with IPR004827 (SM00338).
  • 19 a.a. overlap with IPR008917 (SSF47454).
  • 54 a.a. overlap with IPR011616 (PF00170).
  • 54 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 46 a.a. overlap with 1A02:J.
  • 53 a.a. overlap with 1FOS:F.
  • 51 a.a. overlap with 1JNM:A.
  • 52 a.a. overlap with 1JNM:B.
  • 46 a.a. overlap with 1S9K:E.
  • 54 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 259..312
1
259..312
331
FOS Reference Domain/Motifs
  • 61 a.a. overlap with IPR002112 (PR00043).
  • 14 a.a. overlap with IPR004827 (PS00036).
  • 57 a.a. overlap with IPR004827 (PS50217).
  • 56 a.a. overlap with IPR004827 (SM00338).
  • 19 a.a. overlap with IPR008917 (SSF47454).
  • 55 a.a. overlap with IPR011616 (PF00170).
  • 64 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 52 a.a. overlap with 1A02:J.
  • 54 a.a. overlap with 1FOS:F.
  • 51 a.a. overlap with 1JNM:A.
  • 52 a.a. overlap with 1JNM:B.
  • 52 a.a. overlap with 1S9K:E.
  • 56 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 259..322
1
259..322
331
SMAD2 Reference Domain/Motifs
  • 61 a.a. overlap with IPR002112 (PR00043).
  • 14 a.a. overlap with IPR004827 (PS00036).
  • 57 a.a. overlap with IPR004827 (PS50217).
  • 56 a.a. overlap with IPR004827 (SM00338).
  • 19 a.a. overlap with IPR008917 (SSF47454).
  • 55 a.a. overlap with IPR011616 (PF00170).
  • 64 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 52 a.a. overlap with 1A02:J.
  • 54 a.a. overlap with 1FOS:F.
  • 51 a.a. overlap with 1JNM:A.
  • 52 a.a. overlap with 1JNM:B.
  • 52 a.a. overlap with 1S9K:E.
  • 56 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 259..322
1
259..322
331
SS18 Reference Domain/Motifs
  • 62 a.a. overlap with IPR002112 (PR00043).
  • 14 a.a. overlap with IPR004827 (PS00036).
  • 57 a.a. overlap with IPR004827 (PS50217).
  • 56 a.a. overlap with IPR004827 (SM00338).
  • 19 a.a. overlap with IPR008917 (SSF47454).
  • 55 a.a. overlap with IPR011616 (PF00170).
  • 69 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 52 a.a. overlap with 1A02:J.
  • 54 a.a. overlap with 1FOS:F.
  • 51 a.a. overlap with 1JNM:A.
  • 52 a.a. overlap with 1JNM:B.
  • 52 a.a. overlap with 1S9K:E.
  • 56 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 259..327
1
259..327
331
FOSL2 Reference Domain/Motifs
  • 55 a.a. overlap with IPR002112 (PR00043).
  • 6 a.a. overlap with IPR004827 (PS00036).
  • 49 a.a. overlap with IPR004827 (PS50217).
  • 48 a.a. overlap with IPR004827 (SM00338).
  • 11 a.a. overlap with IPR008917 (SSF47454).
  • 47 a.a. overlap with IPR011616 (PF00170).
  • 63 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 52 a.a. overlap with 1A02:J.
  • 46 a.a. overlap with 1FOS:F.
  • 43 a.a. overlap with 1JNM:A.
  • 44 a.a. overlap with 1JNM:B.
  • 52 a.a. overlap with 1S9K:E.
  • 48 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with CBFB interacting region.
1 267..330
1
267..330
331
FOSL2 Reference Domain/Motifs
  • 55 a.a. overlap with IPR002112 (PR00043).
  • 6 a.a. overlap with IPR004827 (PS00036).
  • 49 a.a. overlap with IPR004827 (PS50217).
  • 48 a.a. overlap with IPR004827 (SM00338).
  • 11 a.a. overlap with IPR008917 (SSF47454).
  • 47 a.a. overlap with IPR011616 (PF00170).
  • 63 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 52 a.a. overlap with 1A02:J.
  • 46 a.a. overlap with 1FOS:F.
  • 43 a.a. overlap with 1JNM:A.
  • 44 a.a. overlap with 1JNM:B.
  • 52 a.a. overlap with 1S9K:E.
  • 48 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with CBFB interacting region.
1 267..331
1
267..331
331
FOSL2 Reference Domain/Motifs
  • 54 a.a. overlap with IPR002112 (PR00043).
  • 5 a.a. overlap with IPR004827 (PS00036).
  • 48 a.a. overlap with IPR004827 (PS50217).
  • 47 a.a. overlap with IPR004827 (SM00338).
  • 10 a.a. overlap with IPR008917 (SSF47454).
  • 46 a.a. overlap with IPR011616 (PF00170).
  • 62 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 51 a.a. overlap with 1A02:J.
  • 45 a.a. overlap with 1FOS:F.
  • 42 a.a. overlap with 1JNM:A.
  • 43 a.a. overlap with 1JNM:B.
  • 51 a.a. overlap with 1S9K:E.
  • 47 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with CBFB interacting region.
1 268..331
1
268..331
331
FOS Reference Domain/Motifs
  • 45 a.a. overlap with IPR002112 (PR00043).
  • 4 a.a. overlap with IPR004827 (PS00036).
  • 47 a.a. overlap with IPR004827 (PS50217).
  • 46 a.a. overlap with IPR004827 (SM00338).
  • 9 a.a. overlap with IPR008917 (SSF47454).
  • 45 a.a. overlap with IPR011616 (PF00170).
  • 47 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 47 a.a. overlap with 1A02:J.
  • 44 a.a. overlap with 1FOS:F.
  • 41 a.a. overlap with 1JNM:A.
  • 42 a.a. overlap with 1JNM:B.
  • 47 a.a. overlap with 1S9K:E.
  • 46 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 269..315
1
269..315
331
FOSL2 Reference Domain/Motifs
  • 53 a.a. overlap with IPR002112 (PR00043).
  • 4 a.a. overlap with IPR004827 (PS00036).
  • 47 a.a. overlap with IPR004827 (PS50217).
  • 46 a.a. overlap with IPR004827 (SM00338).
  • 9 a.a. overlap with IPR008917 (SSF47454).
  • 45 a.a. overlap with IPR011616 (PF00170).
  • 61 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 50 a.a. overlap with 1A02:J.
  • 44 a.a. overlap with 1FOS:F.
  • 41 a.a. overlap with 1JNM:A.
  • 42 a.a. overlap with 1JNM:B.
  • 50 a.a. overlap with 1S9K:E.
  • 46 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with CBFB interacting region.
1 269..331
1
269..331
331
FOS Reference Domain/Motifs
  • 44 a.a. overlap with IPR002112 (PR00043).
  • 3 a.a. overlap with IPR004827 (PS00036).
  • 46 a.a. overlap with IPR004827 (PS50217).
  • 45 a.a. overlap with IPR004827 (SM00338).
  • 8 a.a. overlap with IPR008917 (SSF47454).
  • 44 a.a. overlap with IPR011616 (PF00170).
  • 46 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 46 a.a. overlap with 1A02:J.
  • 44 a.a. overlap with 1FOS:F.
  • 40 a.a. overlap with 1JNM:A.
  • 41 a.a. overlap with 1JNM:B.
  • 46 a.a. overlap with 1S9K:E.
  • 45 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
30 270..315
1
270..315
331
MDM2 Reference Domain/Motifs
  • 44 a.a. overlap with IPR002112 (PR00043).
  • 3 a.a. overlap with IPR004827 (PS00036).
  • 46 a.a. overlap with IPR004827 (PS50217).
  • 45 a.a. overlap with IPR004827 (SM00338).
  • 8 a.a. overlap with IPR008917 (SSF47454).
  • 44 a.a. overlap with IPR011616 (PF00170).
  • 46 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 46 a.a. overlap with 1A02:J.
  • 44 a.a. overlap with 1FOS:F.
  • 40 a.a. overlap with 1JNM:A.
  • 41 a.a. overlap with 1JNM:B.
  • 46 a.a. overlap with 1S9K:E.
  • 45 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 270..315
1
270..315
331
ETS1 Reference Domain/Motifs
  • 52 a.a. overlap with IPR002112 (PR00043).
  • 3 a.a. overlap with IPR004827 (PS00036).
  • 46 a.a. overlap with IPR004827 (PS50217).
  • 45 a.a. overlap with IPR004827 (SM00338).
  • 8 a.a. overlap with IPR008917 (SSF47454).
  • 44 a.a. overlap with IPR011616 (PF00170).
  • 55 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 49 a.a. overlap with 1A02:J.
  • 44 a.a. overlap with 1FOS:F.
  • 40 a.a. overlap with 1JNM:A.
  • 41 a.a. overlap with 1JNM:B.
  • 49 a.a. overlap with 1S9K:E.
  • 45 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 270..324
1
270..324
331
MDM2 Reference Domain/Motifs
  • 52 a.a. overlap with IPR002112 (PR00043).
  • 3 a.a. overlap with IPR004827 (PS00036).
  • 46 a.a. overlap with IPR004827 (PS50217).
  • 45 a.a. overlap with IPR004827 (SM00338).
  • 8 a.a. overlap with IPR008917 (SSF47454).
  • 44 a.a. overlap with IPR011616 (PF00170).
  • 55 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 49 a.a. overlap with 1A02:J.
  • 44 a.a. overlap with 1FOS:F.
  • 40 a.a. overlap with 1JNM:A.
  • 41 a.a. overlap with 1JNM:B.
  • 49 a.a. overlap with 1S9K:E.
  • 45 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 270..324
1
270..324
331
ETS1 Reference Domain/Motifs
  • 52 a.a. overlap with IPR002112 (PR00043).
  • 3 a.a. overlap with IPR004827 (PS00036).
  • 46 a.a. overlap with IPR004827 (PS50217).
  • 45 a.a. overlap with IPR004827 (SM00338).
  • 8 a.a. overlap with IPR008917 (SSF47454).
  • 44 a.a. overlap with IPR011616 (PF00170).
  • 56 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 49 a.a. overlap with 1A02:J.
  • 44 a.a. overlap with 1FOS:F.
  • 40 a.a. overlap with 1JNM:A.
  • 41 a.a. overlap with 1JNM:B.
  • 49 a.a. overlap with 1S9K:E.
  • 45 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
6 270..325
1
270..325
331
FOS Reference Domain/Motifs
  • 52 a.a. overlap with IPR002112 (PR00043).
  • 3 a.a. overlap with IPR004827 (PS00036).
  • 46 a.a. overlap with IPR004827 (PS50217).
  • 45 a.a. overlap with IPR004827 (SM00338).
  • 8 a.a. overlap with IPR008917 (SSF47454).
  • 44 a.a. overlap with IPR011616 (PF00170).
  • 56 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 49 a.a. overlap with 1A02:J.
  • 44 a.a. overlap with 1FOS:F.
  • 40 a.a. overlap with 1JNM:A.
  • 41 a.a. overlap with 1JNM:B.
  • 49 a.a. overlap with 1S9K:E.
  • 45 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 270..325
1
270..325
331
ETS1 Reference Domain/Motifs
  • 52 a.a. overlap with IPR002112 (PR00043).
  • 3 a.a. overlap with IPR004827 (PS00036).
  • 46 a.a. overlap with IPR004827 (PS50217).
  • 45 a.a. overlap with IPR004827 (SM00338).
  • 8 a.a. overlap with IPR008917 (SSF47454).
  • 44 a.a. overlap with IPR011616 (PF00170).
  • 57 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 49 a.a. overlap with 1A02:J.
  • 44 a.a. overlap with 1FOS:F.
  • 40 a.a. overlap with 1JNM:A.
  • 41 a.a. overlap with 1JNM:B.
  • 49 a.a. overlap with 1S9K:E.
  • 45 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
65 270..326
1
270..326
331
ETS1 Reference Domain/Motifs
  • 51 a.a. overlap with IPR002112 (PR00043).
  • 2 a.a. overlap with IPR004827 (PS00036).
  • 45 a.a. overlap with IPR004827 (PS50217).
  • 44 a.a. overlap with IPR004827 (SM00338).
  • 7 a.a. overlap with IPR008917 (SSF47454).
  • 43 a.a. overlap with IPR011616 (PF00170).
  • 56 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 48 a.a. overlap with 1A02:J.
  • 43 a.a. overlap with 1FOS:F.
  • 39 a.a. overlap with 1JNM:A.
  • 40 a.a. overlap with 1JNM:B.
  • 48 a.a. overlap with 1S9K:E.
  • 44 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
2 271..326
1
271..326
331
FOSL2 Reference Domain/Motifs
  • 51 a.a. overlap with IPR002112 (PR00043).
  • 2 a.a. overlap with IPR004827 (PS00036).
  • 45 a.a. overlap with IPR004827 (PS50217).
  • 44 a.a. overlap with IPR004827 (SM00338).
  • 7 a.a. overlap with IPR008917 (SSF47454).
  • 43 a.a. overlap with IPR011616 (PF00170).
  • 59 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 48 a.a. overlap with 1A02:J.
  • 43 a.a. overlap with 1FOS:F.
  • 39 a.a. overlap with 1JNM:A.
  • 40 a.a. overlap with 1JNM:B.
  • 48 a.a. overlap with 1S9K:E.
  • 44 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with CBFB interacting region.
1 271..331
1
271..331
331
MDM2 Reference Domain/Motifs
  • 46 a.a. overlap with IPR002112 (PR00043).
  • 43 a.a. overlap with IPR004827 (PS50217).
  • 42 a.a. overlap with IPR004827 (SM00338).
  • 5 a.a. overlap with IPR008917 (SSF47454).
  • 41 a.a. overlap with IPR011616 (PF00170).
  • 48 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 46 a.a. overlap with 1A02:J.
  • 41 a.a. overlap with 1FOS:F.
  • 37 a.a. overlap with 1JNM:A.
  • 38 a.a. overlap with 1JNM:B.
  • 46 a.a. overlap with 1S9K:E.
  • 42 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 273..320
1
273..320
331
MDM2 Reference Domain/Motifs
  • 49 a.a. overlap with IPR002112 (PR00043).
  • 43 a.a. overlap with IPR004827 (PS50217).
  • 42 a.a. overlap with IPR004827 (SM00338).
  • 5 a.a. overlap with IPR008917 (SSF47454).
  • 41 a.a. overlap with IPR011616 (PF00170).
  • 52 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 46 a.a. overlap with 1A02:J.
  • 41 a.a. overlap with 1FOS:F.
  • 37 a.a. overlap with 1JNM:A.
  • 38 a.a. overlap with 1JNM:B.
  • 46 a.a. overlap with 1S9K:E.
  • 42 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 273..324
1
273..324
331
CBFB Reference Domain/Motifs
  • 47 a.a. overlap with IPR002112 (PR00043).
  • 41 a.a. overlap with IPR004827 (PS50217).
  • 40 a.a. overlap with IPR004827 (SM00338).
  • 3 a.a. overlap with IPR008917 (SSF47454).
  • 39 a.a. overlap with IPR011616 (PF00170).
  • 53 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 44 a.a. overlap with 1A02:J.
  • 39 a.a. overlap with 1FOS:F.
  • 35 a.a. overlap with 1JNM:A.
  • 36 a.a. overlap with 1JNM:B.
  • 44 a.a. overlap with 1S9K:E.
  • 40 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
1 275..327
1
275..327
331
FOSL2 Reference Domain/Motifs
  • 47 a.a. overlap with IPR002112 (PR00043).
  • 41 a.a. overlap with IPR004827 (PS50217).
  • 40 a.a. overlap with IPR004827 (SM00338).
  • 3 a.a. overlap with IPR008917 (SSF47454).
  • 39 a.a. overlap with IPR011616 (PF00170).
  • 55 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 44 a.a. overlap with 1A02:J.
  • 39 a.a. overlap with 1FOS:F.
  • 35 a.a. overlap with 1JNM:A.
  • 36 a.a. overlap with 1JNM:B.
  • 44 a.a. overlap with 1S9K:E.
  • 40 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with CBFB interacting region.
1 275..331
1
275..331
331
FOS Reference Domain/Motifs
  • 41 a.a. overlap with IPR002112 (PR00043).
  • 34 a.a. overlap with IPR004827 (PS50217).
  • 33 a.a. overlap with IPR004827 (SM00338).
  • 32 a.a. overlap with IPR011616 (PF00170).
  • 45 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 37 a.a. overlap with 1A02:J.
  • 32 a.a. overlap with 1FOS:F.
  • 28 a.a. overlap with 1JNM:A.
  • 29 a.a. overlap with 1JNM:B.
  • 37 a.a. overlap with 1S9K:E.
  • 33 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 282..326
1
282..326
331
FOS Reference Domain/Motifs
  • 38 a.a. overlap with IPR002112 (PR00043).
  • 32 a.a. overlap with IPR004827 (PS50217).
  • 31 a.a. overlap with IPR004827 (SM00338).
  • 30 a.a. overlap with IPR011616 (PF00170).
  • 39 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 35 a.a. overlap with 1A02:J.
  • 30 a.a. overlap with 1FOS:F.
  • 26 a.a. overlap with 1JNM:A.
  • 27 a.a. overlap with 1JNM:B.
  • 35 a.a. overlap with 1S9K:E.
  • 31 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
1 284..322
1
284..322
331
MDM2 Reference Domain/Motifs
  • 39 a.a. overlap with IPR002112 (PR00043).
  • 32 a.a. overlap with IPR004827 (PS50217).
  • 31 a.a. overlap with IPR004827 (SM00338).
  • 30 a.a. overlap with IPR011616 (PF00170).
  • 43 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 35 a.a. overlap with 1A02:J.
  • 30 a.a. overlap with 1FOS:F.
  • 26 a.a. overlap with 1JNM:A.
  • 27 a.a. overlap with 1JNM:B.
  • 35 a.a. overlap with 1S9K:E.
  • 31 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with FOS interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
2 284..326
1
284..326
331
FOS Reference Domain/Motifs
  • 39 a.a. overlap with IPR002112 (PR00043).
  • 32 a.a. overlap with IPR004827 (PS50217).
  • 31 a.a. overlap with IPR004827 (SM00338).
  • 30 a.a. overlap with IPR011616 (PF00170).
  • 44 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 35 a.a. overlap with 1A02:J.
  • 30 a.a. overlap with 1FOS:F.
  • 26 a.a. overlap with 1JNM:A.
  • 27 a.a. overlap with 1JNM:B.
  • 35 a.a. overlap with 1S9K:E.
  • 31 a.a. overlap with 1T2K:C.
Variant regions Interacting regions
  • overlap with MDM2 interacting region.
  • overlap with ETS1 interacting region.
  • overlap with SMAD2 interacting region.
  • overlap with SS18 interacting region.
  • overlap with FOSL2 interacting region.
  • overlap with CBFB interacting region.
3 284..327
1
284..327
331

Contacting amino acids (calculated from 3D structures) (10)

Interactants Structure Relation Chain Region Map help_icon
FOS 1A02:F Domain/Motifs
  • 35 a.a. overlap with IPR002112 (PR00043).
  • 33 a.a. overlap with IPR004827 (PS50217).
  • 32 a.a. overlap with IPR004827 (SM00338).
  • 31 a.a. overlap with IPR011616 (PF00170).
  • 36 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 36 a.a. overlap with 1A02:J.
  • 31 a.a. overlap with 1FOS:F.
  • 27 a.a. overlap with 1JNM:A.
  • 28 a.a. overlap with 1JNM:B.
  • 36 a.a. overlap with 1S9K:E.
  • 32 a.a. overlap with 1T2K:C.
Variant regions
J 280..280, 283..284, 286..318
1
280..280 283..284 286..318
331
NFATC2 1A02:N Domain/Motifs
  • 8 a.a. overlap with IPR002112 (PR00043).
  • 10 a.a. overlap with IPR004827 (PS50217).
  • 10 a.a. overlap with IPR004827 (SM00338).
  • 10 a.a. overlap with IPR011616 (PF00170).
  • 10 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs Structured region
  • 10 a.a. overlap with 1A02:J.
  • 10 a.a. overlap with 1FOS:F.
  • 10 a.a. overlap with 1JNM:A.
  • 10 a.a. overlap with 1JNM:B.
  • 10 a.a. overlap with 1S9K:E.
  • 10 a.a. overlap with 1T2K:C.
Variant regions
J 282..282, 285..286, 288..294
1
282..282 285..286 288..294
331
FOS 1FOS:E Domain/Motifs
  • 40 a.a. overlap with IPR002112 (PR00043).
  • 34 a.a. overlap with IPR004827 (PS50217).
  • 33 a.a. overlap with IPR004827 (SM00338).
  • 32 a.a. overlap with IPR011616 (PF00170).
  • 41 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 37 a.a. overlap with 1A02:J.
  • 32 a.a. overlap with 1FOS:F.
  • 28 a.a. overlap with 1JNM:A.
  • 29 a.a. overlap with 1JNM:B.
  • 37 a.a. overlap with 1S9K:E.
  • 33 a.a. overlap with 1T2K:C.
Variant regions
F 279..279, 282..283, 285..322
1
279..279 282..283 285..322
331
JUN 1JNM:B Domain/Motifs
  • 35 a.a. overlap with IPR002112 (PR00043).
  • 1 a.a. overlap with IPR004827 (PS00036).
  • 37 a.a. overlap with IPR004827 (PS50217).
  • 37 a.a. overlap with IPR004827 (SM00338).
  • 5 a.a. overlap with IPR008917 (SSF47454).
  • 37 a.a. overlap with IPR011616 (PF00170).
  • 37 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 37 a.a. overlap with 1A02:J.
  • 37 a.a. overlap with 1FOS:F.
  • 37 a.a. overlap with 1JNM:A.
  • 37 a.a. overlap with 1JNM:B.
  • 37 a.a. overlap with 1S9K:E.
  • 37 a.a. overlap with 1T2K:C.
Variant regions
A 270..270, 273..274, 276..309
1
270..270 273..274 276..309
331
JUN 1JNM:A Domain/Motifs
  • 35 a.a. overlap with IPR002112 (PR00043).
  • 37 a.a. overlap with IPR004827 (PS50217).
  • 37 a.a. overlap with IPR004827 (SM00338).
  • 4 a.a. overlap with IPR008917 (SSF47454).
  • 37 a.a. overlap with IPR011616 (PF00170).
  • 37 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 37 a.a. overlap with 1A02:J.
  • 37 a.a. overlap with 1FOS:F.
  • 36 a.a. overlap with 1JNM:A.
  • 37 a.a. overlap with 1JNM:B.
  • 37 a.a. overlap with 1S9K:E.
  • 37 a.a. overlap with 1T2K:C.
Variant regions
B 273..274, 276..310
1
273..274 276..310
331
NFATC2 1S9K:C Domain/Motifs
  • 8 a.a. overlap with IPR002112 (PR00043).
  • 10 a.a. overlap with IPR004827 (PS50217).
  • 10 a.a. overlap with IPR004827 (SM00338).
  • 10 a.a. overlap with IPR011616 (PF00170).
  • 10 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs Structured region
  • 10 a.a. overlap with 1A02:J.
  • 10 a.a. overlap with 1FOS:F.
  • 10 a.a. overlap with 1JNM:A.
  • 10 a.a. overlap with 1JNM:B.
  • 10 a.a. overlap with 1S9K:E.
  • 10 a.a. overlap with 1T2K:C.
Variant regions
E 282..282, 285..293
1
282..282 285..293
331
FOS 1S9K:D Domain/Motifs
  • 33 a.a. overlap with IPR002112 (PR00043).
  • 33 a.a. overlap with IPR004827 (PS50217).
  • 32 a.a. overlap with IPR004827 (SM00338).
  • 31 a.a. overlap with IPR011616 (PF00170).
  • 34 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 34 a.a. overlap with 1A02:J.
  • 31 a.a. overlap with 1FOS:F.
  • 27 a.a. overlap with 1JNM:A.
  • 28 a.a. overlap with 1JNM:B.
  • 34 a.a. overlap with 1S9K:E.
  • 32 a.a. overlap with 1T2K:C.
Variant regions
E 280..280, 283..284, 286..315, 318..318
1
280..280 283..284 286..315 318..318
331
IRF3 1T2K:A Domain/Motifs
  • 2 a.a. overlap with IPR002112 (PR00043).
  • 1 a.a. overlap with IPR004827 (PS00036).
  • 2 a.a. overlap with IPR004827 (PS50217).
  • 2 a.a. overlap with IPR004827 (SM00338).
  • 2 a.a. overlap with IPR008917 (SSF47454).
  • 2 a.a. overlap with IPR011616 (PF00170).
  • 2 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs Structured region
  • 1 a.a. overlap with 1FOS:F.
  • 2 a.a. overlap with 1JNM:A.
  • 2 a.a. overlap with 1JNM:B.
  • 2 a.a. overlap with 1T2K:C.
Variant regions
C 255..255, 258..258
1
255..255 258..258
331
IRF3 1T2K:B Domain/Motifs
  • 3 a.a. overlap with IPR002112 (PR00043).
  • 2 a.a. overlap with IPR004827 (PS00036).
  • 3 a.a. overlap with IPR004827 (PS50217).
  • 3 a.a. overlap with IPR004827 (SM00338).
  • 3 a.a. overlap with IPR008917 (SSF47454).
  • 3 a.a. overlap with IPR011616 (PF00170).
  • 3 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs Structured region
  • 2 a.a. overlap with 1FOS:F.
  • 3 a.a. overlap with 1JNM:A.
  • 3 a.a. overlap with 1JNM:B.
  • 3 a.a. overlap with 1T2K:C.
Variant regions
C 254..254, 257..257, 261..261
1
254..254 257..257 261..261
331
ATF2 1T2K:D Domain/Motifs
  • 37 a.a. overlap with IPR002112 (PR00043).
  • 38 a.a. overlap with IPR004827 (PS50217).
  • 38 a.a. overlap with IPR004827 (SM00338).
  • 4 a.a. overlap with IPR008917 (SSF47454).
  • 37 a.a. overlap with IPR011616 (PF00170).
  • 38 a.a. overlap with IPR015558 (PTHR11462:SF8).
SNPs
  • SNP:rs9989 (Pos=298) falls into interacting region.
Structured region
  • 38 a.a. overlap with 1A02:J.
  • 37 a.a. overlap with 1FOS:F.
  • 33 a.a. overlap with 1JNM:A.
  • 34 a.a. overlap with 1JNM:B.
  • 38 a.a. overlap with 1S9K:E.
  • 38 a.a. overlap with 1T2K:C.
Variant regions
C 273..274, 276..277, 280..305, 307..314
1
273..274 276..277 280..305 307..314
331

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